The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussell MF, Gilliland DG, Lenny N, Meyers S.
Hiebert SW, et al.
Mol Cell Biol. 1996 Apr;16(4):1349-55. doi: 10.1128/MCB.16.4.1349.
Mol Cell Biol. 1996.
PMID: 8657108
Free PMC article.