Yokoi T - Search Results

1

Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.

Okada Y, Fujita Y, Motoyama T, Tsuda Y, Yokoi T, Li T, Sasaki Y, Ambo A, Jinsmaa Y, Bryant SD, Lazarus LH. Okada Y, et al. Among authors: yokoi t. Bioorg Med Chem. 2003 May 1;11(9):1983-94. doi: 10.1016/s0968-0896(03)00068-3. Bioorg Med Chem. 2003. PMID: 12670649

2

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.

Okada Y, Tsuda Y, Fujita Y, Yokoi T, Sasaki Y, Ambo A, Konishi R, Nagata M, Salvadori S, Jinsmaa Y, Bryant SD, Lazarus LH. Okada Y, et al. Among authors: yokoi t. J Med Chem. 2003 Jul 17;46(15):3201-9. doi: 10.1021/jm020459z. J Med Chem. 2003. PMID: 12852751

3

Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.

Jinsmaa Y, Miyazaki A, Fujita Y, Li T, Fujisawa Y, Shiotani K, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y. Jinsmaa Y, et al. Among authors: yokoi t. J Med Chem. 2004 May 6;47(10):2599-610. doi: 10.1021/jm0304616. J Med Chem. 2004. PMID: 15115401

4

Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.

Fujita Y, Tsuda Y, Li T, Motoyama T, Takahashi M, Shimizu Y, Yokoi T, Sasaki Y, Ambo A, Kita A, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Fujita Y, et al. Among authors: yokoi t. J Med Chem. 2004 Jul 1;47(14):3591-9. doi: 10.1021/jm030649p. J Med Chem. 2004. PMID: 15214786

5

Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).

Fujita Y, Tsuda Y, Motoyama T, Li T, Miyazaki A, Yokoi T, Sasaki Y, Ambo A, Niizuma H, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Fujita Y, et al. Among authors: yokoi t. Bioorg Med Chem Lett. 2005 Feb 1;15(3):599-602. doi: 10.1016/j.bmcl.2004.11.040. Bioorg Med Chem Lett. 2005. PMID: 15664820

6

Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Shiotani K, Li T, Miyazaki A, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y. Shiotani K, et al. Among authors: yokoi t. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5768-71. doi: 10.1016/j.bmcl.2007.08.058. Epub 2007 Aug 28. Bioorg Med Chem Lett. 2007. PMID: 17826995 Free PMC article.

7

Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships.

Shiotani K, Miyazaki A, Li T, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Jinsmaa Y, Lazarus LH, Okada Y. Shiotani K, et al. Among authors: yokoi t. Med Chem. 2007 Nov;3(6):583-98. doi: 10.2174/157340607782360272. Med Chem. 2007. PMID: 18045209

8

New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.

Miyazaki A, Tsuda Y, Fukushima S, Yokoi T, Vántus T, Bökönyi G, Szabó E, Horváth A, Kéri G, Okada Y. Miyazaki A, et al. Among authors: yokoi t. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6199-201. doi: 10.1016/j.bmcl.2008.10.001. Epub 2008 Oct 5. Bioorg Med Chem Lett. 2008. PMID: 18930401

9

Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation.

Okada Y, Fukumizu A, Takahashi M, Shimizu Y, Tsuda Y, Yokoi T, Bryant SD, Lazarus LH. Okada Y, et al. Among authors: yokoi t. Biochem Biophys Res Commun. 2000 Sep 16;276(1):7-11. doi: 10.1006/bbrc.2000.3416. Biochem Biophys Res Commun. 2000. PMID: 11006073

10

Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation.

Miyazaki A, Fujisawa Y, Shiotani K, Fujita Y, Li T, Tsuda Y, Yokoi T, Bryant SD, Lazarus LH, Okada Y. Miyazaki A, et al. Among authors: yokoi t. Chem Pharm Bull (Tokyo). 2005 Sep;53(9):1152-8. doi: 10.1248/cpb.53.1152. Chem Pharm Bull (Tokyo). 2005. PMID: 16141586 Free article.

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