Hitman GA - Search Results

1

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: hitman ga. Diabetes. 2003 May;52(5):1300-5. doi: 10.2337/diabetes.52.5.1300. Diabetes. 2003. PMID: 12716770

2

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.

Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT. Frayling TM, et al. Among authors: hitman ga. Diabetes. 2003 Jul;52(7):1857-63. doi: 10.2337/diabetes.52.7.1857. Diabetes. 2003. PMID: 12829657

3

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.

Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S, Hattersley AT, Cardon LR, McCarthy MI. Wiltshire S, et al. Among authors: hitman ga. Diabetes. 2004 Mar;53(3):855-60. doi: 10.2337/diabetes.53.3.855. Diabetes. 2004. PMID: 14988275

4

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI. Zeggini E, et al. Among authors: hitman ga. Diabetes. 2004 Dec;53(12):3319-22. doi: 10.2337/diabetes.53.12.3319. Diabetes. 2004. PMID: 15561966

5

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.

Groves CJ, Zeggini E, Walker M, Hitman GA, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Wiltshire S. Groves CJ, et al. Among authors: hitman ga. Diabetes. 2006 Jun;55(6):1884-9. doi: 10.2337/db05-1674. Diabetes. 2006. PMID: 16731858

6

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M, Holman RR, McCarthy MI, Clark A. Desai M, et al. Among authors: hitman ga. Diabetes. 2006 Jun;55(6):1890-4. doi: 10.2337/db06-0089. Diabetes. 2006. PMID: 16731859

7

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI; International Type 2 Diabetes 1q Consortium. Zeggini E, et al. Among authors: hitman ga. Diabetes. 2006 Sep;55(9):2541-8. doi: 10.2337/db06-0088. Diabetes. 2006. PMID: 16936202 Free article.

8

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: hitman ga. Diabetes. 2006 Sep;55(9):2640-4. doi: 10.2337/db06-0355. Diabetes. 2006. PMID: 16936215

9

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI. Owen KR, et al. Among authors: hitman ga. Diabetes. 2007 Mar;56(3):879-83. doi: 10.2337/db06-0930. Diabetes. 2007. PMID: 17327460 Free PMC article.

10

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC); McCarthy MI, Hattersley AT. Zeggini E, et al. Among authors: hitman ga. Science. 2007 Jun 1;316(5829):1336-41. doi: 10.1126/science.1142364. Epub 2007 Apr 26. Science. 2007. PMID: 17463249 Free PMC article.

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