Mundorff EC - Search Results

1

Systematic variation of amino acid substitutions for stringent assessment of pairwise covariation.

Govindarajan S, Ness JE, Kim S, Mundorff EC, Minshull J, Gustafsson C. Govindarajan S, et al. Among authors: mundorff ec. J Mol Biol. 2003 May 16;328(5):1061-9. doi: 10.1016/s0022-2836(03)00357-7. J Mol Biol. 2003. PMID: 12729741

2

Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently.

Ness JE, Kim S, Gottman A, Pak R, Krebber A, Borchert TV, Govindarajan S, Mundorff EC, Minshull J. Ness JE, et al. Among authors: mundorff ec. Nat Biotechnol. 2002 Dec;20(12):1251-5. doi: 10.1038/nbt754. Epub 2002 Nov 11. Nat Biotechnol. 2002. PMID: 12426575

3

Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily.

Schmidt DM, Mundorff EC, Dojka M, Bermudez E, Ness JE, Govindarajan S, Babbitt PC, Minshull J, Gerlt JA. Schmidt DM, et al. Among authors: mundorff ec. Biochemistry. 2003 Jul 22;42(28):8387-93. doi: 10.1021/bi034769a. Biochemistry. 2003. PMID: 12859183

4

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Savile CK, Janey JM, Mundorff EC, Moore JC, Tam S, Jarvis WR, Colbeck JC, Krebber A, Fleitz FJ, Brands J, Devine PN, Huisman GW, Hughes GJ. Savile CK, et al. Among authors: mundorff ec. Science. 2010 Jul 16;329(5989):305-9. doi: 10.1126/science.1188934. Epub 2010 Jun 17. Science. 2010. PMID: 20558668

5

Improving catalytic function by ProSAR-driven enzyme evolution.

Fox RJ, Davis SC, Mundorff EC, Newman LM, Gavrilovic V, Ma SK, Chung LM, Ching C, Tam S, Muley S, Grate J, Gruber J, Whitman JC, Sheldon RA, Huisman GW. Fox RJ, et al. Among authors: mundorff ec. Nat Biotechnol. 2007 Mar;25(3):338-44. doi: 10.1038/nbt1286. Epub 2007 Feb 18. Nat Biotechnol. 2007. PMID: 17322872

6

A comparative analysis of the immunological evolution of antibody 28B4.

Yin J, Mundorff EC, Yang PL, Wendt KU, Hanway D, Stevens RC, Schultz PG. Yin J, et al. Among authors: mundorff ec. Biochemistry. 2001 Sep 11;40(36):10764-73. doi: 10.1021/bi010536c. Biochemistry. 2001. PMID: 11535051

7

Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.

Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schultz PG, Stevens RC. Mundorff EC, et al. Biochemistry. 2000 Feb 1;39(4):627-32. doi: 10.1021/bi9924314. Biochemistry. 2000. PMID: 10651626

8

The interplay between binding energy and catalysis in the evolution of a catalytic antibody.

Ulrich HD, Mundorff E, Santarsiero BD, Driggers EM, Stevens RC, Schultz PG. Ulrich HD, et al. Nature. 1997 Sep 18;389(6648):271-5. doi: 10.1038/38470. Nature. 1997. PMID: 9305839

9

Alteration of substrate specificity of alanine dehydrogenase.

Fernandes P, Aldeborgh H, Carlucci L, Walsh L, Wasserman J, Zhou E, Lefurgy ST, Mundorff EC. Fernandes P, et al. Among authors: mundorff ec. Protein Eng Des Sel. 2015 Feb;28(2):29-35. doi: 10.1093/protein/gzu053. Epub 2014 Dec 23. Protein Eng Des Sel. 2015. PMID: 25538307 Free PMC article.

10

Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea.

Carlucci L, Zhou E, Malashkevich VN, Almo SC, Mundorff EC. Carlucci L, et al. Among authors: mundorff ec. Protein Sci. 2016 Apr;25(4):877-86. doi: 10.1002/pro.2895. Epub 2016 Feb 21. Protein Sci. 2016. PMID: 26833751 Free PMC article.

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