The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding.
von Poser C, Ichtchenko K, Shao X, Rizo J, Südhof TC.
von Poser C, et al. Among authors: rizo j.
J Biol Chem. 1997 May 30;272(22):14314-9. doi: 10.1074/jbc.272.22.14314.
J Biol Chem. 1997.
PMID: 9162066
Free article.
The first C2-domain of synaptotagmin I (the C2A-domain) binds phospholipids as a function of Ca2+ and contains a Ca2+-binding site, the C2-motif, that binds at least two Ca2+ ions via five aspartate residues and is conserved in most C2-domains (Shao, X., Davletov, B., Sutton, B., …
The first C2-domain of synaptotagmin I (the C2A-domain) binds phospholipids as a function of Ca2+ and contains a Ca2+-binding site, the C2-m …