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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP. Weskamp G, et al. Among authors: hartmann d. Nat Immunol. 2006 Dec;7(12):1293-8. doi: 10.1038/ni1399. Epub 2006 Oct 29. Nat Immunol. 2006. PMID: 17072319
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: hartmann d. J Biol Chem. 2009 Dec 25;284(52):36024-36033. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. J Biol Chem. 2009. PMID: 19864413 Free PMC article.
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.
Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B. Tousseyn T, et al. Among authors: hartmann d. J Biol Chem. 2009 Apr 24;284(17):11738-47. doi: 10.1074/jbc.M805894200. Epub 2009 Feb 11. J Biol Chem. 2009. PMID: 19213735 Free PMC article.
Implication of APP secretases in notch signaling.
Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Hartmann D, et al. J Mol Neurosci. 2001 Oct;17(2):171-81. doi: 10.1385/JMN:17:2:171. J Mol Neurosci. 2001. PMID: 11816790 Review.
1,019 results