Duff HJ - Search Results

1

Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells.

Teng G, Zhao X, Cross JC, Li P, Lees-Miller JP, Guo J, Dyck JR, Duff HJ. Teng G, et al. Among authors: duff hj. Cardiovasc Res. 2004 Feb 1;61(2):268-77. doi: 10.1016/j.cardiores.2003.11.016. Cardiovasc Res. 2004. PMID: 14736543

2

Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.

Dong D, Duan Y, Guo J, Roach DE, Swirp SL, Wang L, Lees-Miller JP, Sheldon RS, Molkentin JD, Duff HJ. Dong D, et al. Among authors: duff hj. Cardiovasc Res. 2003 Feb;57(2):320-32. doi: 10.1016/s0008-6363(02)00661-2. Cardiovasc Res. 2003. PMID: 12566105

3

Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia.

Lees-Miller JP, Guo J, Somers JR, Roach DE, Sheldon RS, Rancourt DE, Duff HJ. Lees-Miller JP, et al. Among authors: duff hj. Mol Cell Biol. 2003 Mar;23(6):1856-62. doi: 10.1128/MCB.23.6.1856-1862.2003. Mol Cell Biol. 2003. PMID: 12612061 Free PMC article.

4

[K(+)](o)-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype.

Teng GQ, Lees-Miller JP, Duan Y, Li BT, Li P, Duff HJ. Teng GQ, et al. Among authors: duff hj. Cardiovasc Res. 2003 Mar;57(3):642-50. doi: 10.1016/s0008-6363(02)00778-2. Cardiovasc Res. 2003. PMID: 12618226

5

Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees C.

Guo J, Zhan S, Lees-Miller JP, Teng G, Duff HJ. Guo J, et al. Among authors: duff hj. Heart Rhythm. 2005 Aug;2(8):860-6. doi: 10.1016/j.hrthm.2005.04.029. Heart Rhythm. 2005. PMID: 16051125

6

Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.

Teng GQ, Zhao X, Lees-Miller JP, Quinn FR, Li P, Rancourt DE, London B, Cross JC, Duff HJ. Teng GQ, et al. Among authors: duff hj. Circ Res. 2008 Dec 5;103(12):1483-91. doi: 10.1161/CIRCRESAHA.108.177055. Epub 2008 Oct 23. Circ Res. 2008. PMID: 18948620 Free PMC article.

7

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts.

Lees-Miller JP, Kondo C, Wang L, Duff HJ. Lees-Miller JP, et al. Among authors: duff hj. Circ Res. 1997 Nov;81(5):719-26. doi: 10.1161/01.res.81.5.719. Circ Res. 1997. PMID: 9351446

8

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant.

Lees-Miller JP, Duan Y, Teng GQ, Thorstad K, Duff HJ. Lees-Miller JP, et al. Among authors: duff hj. Circ Res. 2000 Mar 17;86(5):507-13. doi: 10.1161/01.res.86.5.507. Circ Res. 2000. PMID: 10720411

9

Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytes.

Guo J, Duff HJ. Guo J, et al. Among authors: duff hj. J Physiol. 2006 Jul 15;574(Pt 2):509-18. doi: 10.1113/jphysiol.2006.109199. Epub 2006 Apr 20. J Physiol. 2006. PMID: 16627565 Free PMC article.

10

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ. Lees-Miller JP, et al. Among authors: duff hj. Biophys J. 2009 May 6;96(9):3600-10. doi: 10.1016/j.bpj.2009.01.028. Biophys J. 2009. PMID: 19413965 Free PMC article.

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