Witchel H - Search Results

1

herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.

Lastraioli E, Guasti L, Crociani O, Polvani S, Hofmann G, Witchel H, Bencini L, Calistri M, Messerini L, Scatizzi M, Moretti R, Wanke E, Olivotto M, Mugnai G, Arcangeli A. Lastraioli E, et al. Among authors: witchel h. Cancer Res. 2004 Jan 15;64(2):606-11. doi: 10.1158/0008-5472.can-03-2360. Cancer Res. 2004. PMID: 14744775

2

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.

Milnes JT, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Milnes JT, et al. Br J Pharmacol. 2003 Jul;139(5):887-98. doi: 10.1038/sj.bjp.0705335. Br J Pharmacol. 2003. PMID: 12839862 Free PMC article.

3

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin.

Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Milnes JT, et al. FEBS Lett. 2003 Jul 17;547(1-3):20-6. doi: 10.1016/s0014-5793(03)00662-8. FEBS Lett. 2003. PMID: 12860380 Free article.

4

Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents.

Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Witchel HJ, et al. FEBS Lett. 2002 Feb 13;512(1-3):59-66. doi: 10.1016/s0014-5793(01)03320-8. FEBS Lett. 2002. PMID: 11852052 Free article.

5

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

Ridley JM, Milnes JT, Benest AV, Masters JD, Witchel HJ, Hancox JC. Ridley JM, et al. Biochem Biophys Res Commun. 2003 Jun 27;306(2):388-93. doi: 10.1016/s0006-291x(03)00980-x. Biochem Biophys Res Commun. 2003. PMID: 12804575

6

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC. Witchel HJ, et al. J Pharmacol Toxicol Methods. 2002 Sep-Oct;48(2):65-80. doi: 10.1016/S1056-8719(03)00041-8. J Pharmacol Toxicol Methods. 2002. PMID: 14565563 Review.

7

Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine.

Ridley JM, Milnes JT, Zhang YH, Witchel HJ, Hancox JC. Ridley JM, et al. Among authors: witchel hj. J Physiol. 2003 Jun 15;549(Pt 3):667-72. doi: 10.1113/jphysiol.2003.043976. Epub 2003 May 9. J Physiol. 2003. PMID: 12740430 Free PMC article.

8

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide.

Paul AA, Witchel HJ, Hancox JC. Paul AA, et al. Among authors: witchel hj. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50. doi: 10.1006/bbrc.2001.4269. Biochem Biophys Res Commun. 2001. PMID: 11162661

9

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ. Duncan RS, et al. Biochem Biophys Res Commun. 2006 Mar 10;341(2):500-6. doi: 10.1016/j.bbrc.2006.01.008. Epub 2006 Jan 13. Biochem Biophys Res Commun. 2006. PMID: 16446155

10

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome.

McPate MJ, Zhang H, Cordeiro JM, Dempsey CE, Witchel HJ, Hancox JC. McPate MJ, et al. Among authors: witchel hj. Biochem Biophys Res Commun. 2009 Aug 14;386(1):111-7. doi: 10.1016/j.bbrc.2009.05.134. Epub 2009 Jun 6. Biochem Biophys Res Commun. 2009. PMID: 19501051 Free PMC article.

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