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Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Ruzin A, Singh G, Severin A, Yang Y, Dushin RG, Sutherland AG, Minnick A, Greenstein M, May MK, Shlaes DM, Bradford PA. Ruzin A, et al. Among authors: dushin rg. Antimicrob Agents Chemother. 2004 Mar;48(3):728-38. doi: 10.1128/AAC.48.3.728-738.2004. Antimicrob Agents Chemother. 2004. PMID: 14982757 Free PMC article.
Comparative in vitro activities of AC98-6446, a novel semisynthetic glycopeptide derivative of the natural product mannopeptimycin alpha, and other antimicrobial agents against gram-positive clinical isolates.
Petersen PJ, Wang TZ, Dushin RG, Bradford PA. Petersen PJ, et al. Among authors: dushin rg. Antimicrob Agents Chemother. 2004 Mar;48(3):739-46. doi: 10.1128/AAC.48.3.739-746.2004. Antimicrob Agents Chemother. 2004. PMID: 14982758 Free PMC article.
Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.
Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS. Dushin RG, et al. J Med Chem. 2004 Jul 1;47(14):3487-90. doi: 10.1021/jm049765y. J Med Chem. 2004. PMID: 15214775
Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.
Alksne LE, Burgio P, Hu W, Feld B, Singh MP, Tuckman M, Petersen PJ, Labthavikul P, McGlynn M, Barbieri L, McDonald L, Bradford P, Dushin RG, Rothstein D, Projan SJ. Alksne LE, et al. Among authors: dushin rg. Antimicrob Agents Chemother. 2000 Jun;44(6):1418-27. doi: 10.1128/AAC.44.6.1418-1427.2000. Antimicrob Agents Chemother. 2000. PMID: 10817687 Free PMC article.
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
Tsao DH, Sutherland AG, Jennings LD, Li Y, Rush TS 3rd, Alvarez JC, Ding W, Dushin EG, Dushin RG, Haney SA, Kenny CH, Malakian AK, Nilakantan R, Mosyak L. Tsao DH, et al. Among authors: dushin eg, dushin rg. Bioorg Med Chem. 2006 Dec 1;14(23):7953-61. doi: 10.1016/j.bmc.2006.07.050. Epub 2006 Aug 17. Bioorg Med Chem. 2006. PMID: 16919463
2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.
Wissner A, Floyd MB, Johnson BD, Fraser H, Ingalls C, Nittoli T, Dushin RG, Discafani C, Nilakantan R, Marini J, Ravi M, Cheung K, Tan X, Musto S, Annable T, Siegel MM, Loganzo F. Wissner A, et al. Among authors: dushin rg. J Med Chem. 2005 Dec 1;48(24):7560-81. doi: 10.1021/jm050559f. J Med Chem. 2005. PMID: 16302797
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