Howard PW - Search Results

1

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.

Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE. Masterson LA, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2004 Feb 23;14(4):901-4. doi: 10.1016/j.bmcl.2003.12.017. Bioorg Med Chem Lett. 2004. PMID: 15012990

2

Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.

Guiotto A, Howard PW, Baraldi PG, Thurston DE. Guiotto A, et al. Among authors: howard pw. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3017-8. doi: 10.1016/S0960-894X(97)10083-X. Bioorg Med Chem Lett. 1998. PMID: 9873667

3

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.

Baraldi PG, Cacciari B, Guiotto A, Leoni A, Romagnoli R, Spalluto G, Mongelli N, Howard PW, Thurston DE, Bianchi N, Gambari R. Baraldi PG, et al. Among authors: howard pw. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3019-24. doi: 10.1016/S0960-894X(98)00544-7. Bioorg Med Chem Lett. 1998. PMID: 9873668

4

Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

Thurston DE, Bose DS, Howard PW, Jenkins TC, Leoni A, Baraldi PG, Guiotto A, Cacciari B, Kelland LR, Foloppe MP, Rault S. Thurston DE, et al. Among authors: howard pw. J Med Chem. 1999 Jun 3;42(11):1951-64. doi: 10.1021/jm981117p. J Med Chem. 1999. PMID: 10354403

5

Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.

Wilson SC, Howard PW, Forrow SM, Hartley JA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Wilson SC, et al. Among authors: howard pw. J Med Chem. 1999 Oct 7;42(20):4028-41. doi: 10.1021/jm981124d. J Med Chem. 1999. PMID: 10514273

6

Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.

Baraldi PG, Balboni G, Cacciari B, Guiotto A, Manfredini S, Romagnoli R, Spalluto G, Thurston DE, Howard PW, Bianchi N, Rutigliano C, Mischiati C, Gambari R. Baraldi PG, et al. Among authors: howard pw. J Med Chem. 1999 Dec 16;42(25):5131-41. doi: 10.1021/jm991033w. J Med Chem. 1999. PMID: 10602698

7

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Corcoran KE, Barcella S, Yasin MM, Hurst AA, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1845-7. doi: 10.1016/s0960-894x(00)00351-6. Bioorg Med Chem Lett. 2000. PMID: 10969982

8

Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Barcella S, Nakamya A, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1849-51. doi: 10.1016/s0960-894x(00)00350-4. Bioorg Med Chem Lett. 2000. PMID: 10969983

9

Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT.

Sagnou MJ, Howard PW, Gregson SJ, Eno-Amooquaye E, Burke PJ, Thurston DE. Sagnou MJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2083-6. doi: 10.1016/s0960-894x(00)00404-2. Bioorg Med Chem Lett. 2000. PMID: 10999476

10

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

Gregson SJ, Howard PW, Hartley JA, Brooks NA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. J Med Chem. 2001 Mar 1;44(5):737-48. doi: 10.1021/jm001064n. J Med Chem. 2001. PMID: 11262084

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