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Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G. D'Alessandris C, et al. Among authors: ranalli m. FASEB J. 2004 Jun;18(9):959-61. doi: 10.1096/fj.03-0725fje. Epub 2004 Apr 1. FASEB J. 2004. PMID: 15059979
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.
Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F. Federici M, et al. Among authors: ranalli m. Diabetes. 2001 Jun;50(6):1290-301. doi: 10.2337/diabetes.50.6.1290. Diabetes. 2001. PMID: 11375329
p73-alpha is capable of inducing scotin and ER stress.
Terrinoni A, Ranalli M, Cadot B, Leta A, Bagetta G, Vousden KH, Melino G. Terrinoni A, et al. Among authors: ranalli m. Oncogene. 2004 Apr 29;23(20):3721-5. doi: 10.1038/sj.onc.1207342. Oncogene. 2004. PMID: 15116103
108 results