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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P; Type 1 Diabetes Genetics Consortium; Todd JA, Wallace C, Concannon P, Rich SS. Onengut-Gumuscu S, et al. Nat Genet. 2015 Apr;47(4):381-6. doi: 10.1038/ng.3245. Epub 2015 Mar 9. Nat Genet. 2015. PMID: 25751624 Free PMC article.
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium. Barrett JC, et al. Nat Genet. 2009 Jun;41(6):703-7. doi: 10.1038/ng.381. Epub 2009 May 10. Nat Genet. 2009. PMID: 19430480 Free PMC article.
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.
Merriman T, Twells R, Merriman M, Eaves I, Cox R, Cucca F, McKinney P, Shield J, Baum D, Bosi E, Pozzilli P, Nisticò L, Buzzetti R, Joner G, Rønningen KS, Thorsby E, Undlien D, Pociot F, Nerup J, Bain S, Barnett A, Todd J. Merriman T, et al. Among authors: ronningen ks. Hum Mol Genet. 1997 Jul;6(7):1003-10. doi: 10.1093/hmg/6.7.1003. Hum Mol Genet. 1997. PMID: 9215667
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
Nakagawa Y, Kawaguchi Y, Twells RC, Muxworthy C, Hunter KM, Wilson A, Merriman ME, Cox RD, Merriman T, Cucca F, McKinney PA, Shield JP, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nisticò L, Buzzetti R, Pozzilli P, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Rönningen KS, Bain SC, Todd JA; Bart's-Oxford Family Study Group. Nakagawa Y, et al. Among authors: ronningen ks. Am J Hum Genet. 1998 Aug;63(2):547-56. doi: 10.1086/301974. Am J Hum Genet. 1998. PMID: 9683605 Free PMC article.
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Merriman TR, Eaves IA, Twells RC, Merriman ME, Danoy PA, Muxworthy CE, Hunter KM, Cox RD, Cucca F, McKinney PA, Shield JP, Baum JD, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Ronningen KS, Bain SC, Todd JA. Merriman TR, et al. Among authors: ronningen ks. Hum Mol Genet. 1998 Mar;7(3):517-24. doi: 10.1093/hmg/7.3.517. Hum Mol Genet. 1998. PMID: 9467012
160 results