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The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. Abel S, et al. Among authors: ludwig a. J Immunol. 2004 May 15;172(10):6362-72. doi: 10.4049/jimmunol.172.10.6362. J Immunol. 2004. PMID: 15128827
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: ludwig a. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S. Budagian V, et al. Among authors: ludwig a. J Biol Chem. 2004 Sep 24;279(39):40368-75. doi: 10.1074/jbc.M404125200. Epub 2004 Jun 23. J Biol Chem. 2004. Retraction in: J Biol Chem. 2011 Mar 18;286(11):9894. doi: 10.1074/jbc.a110.404125. PMID: 15215246 Free article. Retracted.
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.
Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD. Ludwig A, et al. Comb Chem High Throughput Screen. 2005 Mar;8(2):161-71. doi: 10.2174/1386207053258488. Comb Chem High Throughput Screen. 2005. PMID: 15777180 Review.
1,311 results