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Page 1
Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy.
Rico-Llanos G, Spoutil F, Blahova E, Koudelka A, Prochazkova M, Czyrek A, Fafilek B, Prochazka J, Lopez MG, Krivanek J, Sedlacek R, Krakow D, Nonaka Y, Nakamura Y, Krejci P. Rico-Llanos G, et al. Among authors: sedlacek r. J Bone Miner Res. 2024 Oct 18:zjae173. doi: 10.1093/jbmr/zjae173. Online ahead of print. J Bone Miner Res. 2024. PMID: 39423254
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA; International Mouse Phenotyping Consortium; Murray SA, Heaney JD, Nutter LMJ. Elrick H, et al. Among authors: sedlacek r. Sci Rep. 2024 Sep 30;14(1):22626. doi: 10.1038/s41598-024-72418-8. Sci Rep. 2024. PMID: 39349521 Free PMC article.
DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Nedomova M, Haberecht-Müller S, Möller S, Venz S, Prochazkova M, Prochazka J, Sedlak F, Chawengsaksophak K, Hammer E, Kasparek P, Adamek M, Sedlacek R, Konvalinka J, Krüger E, Grantz Saskova K. Nedomova M, et al. Among authors: sedlacek r. iScience. 2024 Sep 5;27(10):110893. doi: 10.1016/j.isci.2024.110893. eCollection 2024 Oct 18. iScience. 2024. PMID: 39328932 Free PMC article.
An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation.
Sinigaglia K, Cherian A, Du Q, Lacovich V, Vukić D, Melicherová J, Linhartova P, Zerad L, Stejskal S, Malik R, Prochazka J, Bondurand N, Sedláček R, O'Connell MA, Keegan LP. Sinigaglia K, et al. Among authors: sedlacek r. Cell Rep. 2024 Aug 27;43(8):114618. doi: 10.1016/j.celrep.2024.114618. Epub 2024 Aug 14. Cell Rep. 2024. PMID: 39146181 Free article.
Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver.
Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco P, Urlaub H, Fischer A, Brügger B, Jakobs S, Rehling P. Aich A, et al. Among authors: sedlacek r. Nat Commun. 2024 Aug 12;15(1):6914. doi: 10.1038/s41467-024-51109-y. Nat Commun. 2024. PMID: 39134548 Free PMC article.
Skeletal dysmorphology and mineralization defects in Fgf20 KO mice.
Dlugosova S, Spoutil F, Madureira Trufen CE, Melike Ogan B, Prochazkova M, Fedosieieva O, Nickl P, Aranaz Novaliches G, Sedlacek R, Prochazka J. Dlugosova S, et al. Among authors: sedlacek r. Front Endocrinol (Lausanne). 2024 Jul 26;15:1286365. doi: 10.3389/fendo.2024.1286365. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39129916 Free PMC article.
Improving laboratory animal genetic reporting: LAG-R guidelines.
Teboul L, Amos-Landgraf J, Benavides FJ, Birling MC, Brown SDM, Bryda E, Bunton-Stasyshyn R, Chin HJ, Crispo M, Delerue F, Dobbie M, Franklin CL, Fuchtbauer EM, Gao X, Golzio C, Haffner R, Hérault Y, Hrabe de Angelis M, Lloyd KCK, Magnuson TR, Montoliu L, Murray SA, Nam KH, Nutter LMJ, Pailhoux E, Pardo Manuel de Villena F, Peterson K, Reinholdt L, Sedlacek R, Seong JK, Shiroishi T, Smith C, Takeo T, Tinsley L, Vilotte JL, Warming S, Wells S, Whitelaw CB, Yoshiki A; Asian Mouse Mutagenesis Resource Association; CELPHEDIA infrastructure; INFRAFRONTIER consortium; International Mammalian Genome Society; International Mouse Phenotyping Consortium; International Society for Transgenic Technologies; Mutant Mouse Resource and Research Centers; Phenomics Australia; RRRC- Rat Resource and Research Center; Pavlovic G. Teboul L, et al. Among authors: sedlacek r. Nat Commun. 2024 Jul 2;15(1):5574. doi: 10.1038/s41467-024-49439-y. Nat Commun. 2024. PMID: 38956430 Free PMC article. Review.
Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant.
Candelas Serra M, Kuchtiak V, Kubik-Zahorodna A, Kysilov B, Fili K, Hrcka Krausova B, Abramova V, Dobrovolski M, Harant K, Bozikova P, Cerny J, Prochazka J, Kasparek P, Sedlacek R, Balik A, Smejkalova T, Vyklicky L. Candelas Serra M, et al. Among authors: sedlacek r. J Neurosci. 2024 Jul 31;44(31):e2291232024. doi: 10.1523/JNEUROSCI.2291-23.2024. J Neurosci. 2024. PMID: 38926089
271 results