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Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.
Clark RF, Wang S, Ma Z, Weitzberg M, Motter C, Tufano M, Wagner R, Gu YG, Dandliker PJ, Lerner CG, Chovan LE, Cai Y, Black-Schaefer CL, Lynch L, Kalvin D, Nilius AM, Pratt SD, Soni N, Zhang T, Zhang X, Beutel BA. Clark RF, et al. Among authors: chovan le. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3299-302. doi: 10.1016/j.bmcl.2004.03.091. Bioorg Med Chem Lett. 2004. PMID: 15149694
Novel antibacterial class.
Dandliker PJ, Pratt SD, Nilius AM, Black-Schaefer C, Ruan X, Towne DL, Clark RF, Englund EE, Wagner R, Weitzberg M, Chovan LE, Hickman RK, Daly MM, Kakavas S, Zhong P, Cao Z, David CA, Xuei X, Lerner CG, Soni NB, Bui M, Shen LL, Cai Y, Merta PJ, Saiki AY, Beutel BA. Dandliker PJ, et al. Among authors: chovan le. Antimicrob Agents Chemother. 2003 Dec;47(12):3831-9. doi: 10.1128/AAC.47.12.3831-3839.2003. Antimicrob Agents Chemother. 2003. PMID: 14638491 Free PMC article.
Novel antibacterial class: a series of tetracyclic derivatives.
Hinman MM, Rosenberg TA, Balli D, Black-Schaefer C, Chovan LE, Kalvin D, Merta PJ, Nilius AM, Pratt SD, Soni NB, Wagenaar FL, Weitzberg M, Wagner R, Beutel BA. Hinman MM, et al. Among authors: chovan le. J Med Chem. 2006 Aug 10;49(16):4842-56. doi: 10.1021/jm060010w. J Med Chem. 2006. PMID: 16884296
From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae.
Lerner CG, Hajduk PJ, Wagner R, Wagenaar FL, Woodall C, Gu YG, Searle XB, Florjancic AS, Zhang T, Clark RF, Cooper CS, Mack JC, Yu L, Cai M, Betz SF, Chovan LE, McCall JO, Black-Schaefer CL, Kakavas SJ, Schurdak ME, Comess KM, Walter KA, Edalji R, Dorwin SA, Smith RA, Hebert EJ, Harlan JE, Metzger RE, Merta PJ, Baranowski JL, Coen ML, Thornewell SJ, Shivakumar AG, Saiki AY, Soni N, Bui M, Balli DJ, Sanders WJ, Nilius AM, Holzman TF, Fesik SW, Beutel BA. Lerner CG, et al. Among authors: chovan le. Chem Biol Drug Des. 2007 Jun;69(6):395-404. doi: 10.1111/j.1747-0285.2007.00521.x. Chem Biol Drug Des. 2007. PMID: 17581233
A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen.
Pratt SD, David CA, Black-Schaefer C, Dandliker PJ, Xuei X, Warrior U, Burns DJ, Zhong P, Cao Z, Saiki AY, Lerner CG, Chovan LE, Soni NB, Nilius AM, Wagenaar FL, Merta PJ, Traphagen LM, Beutel BA. Pratt SD, et al. Among authors: chovan le. J Biomol Screen. 2004 Feb;9(1):3-11. doi: 10.1177/1087057103260876. J Biomol Screen. 2004. PMID: 15006143
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