Lazarus LH - Search Results

1

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: lazarus lh. J Med Chem. 2004 Jul 29;47(16):4066-71. doi: 10.1021/jm040033f. J Med Chem. 2004. PMID: 15267245

2

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.

Balboni G, Guerrini R, Salvadori S, Bianchi C, Rizzi D, Bryant SD, Lazarus LH. Balboni G, et al. Among authors: lazarus lh. J Med Chem. 2002 Jan 31;45(3):713-20. doi: 10.1021/jm010449i. J Med Chem. 2002. PMID: 11806723

3

Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.

Bryant SD, George C, Flippen-Anderson JL, Deschamps JR, Salvadori S, Balboni G, Guerrini R, Lazarus LH. Bryant SD, et al. Among authors: lazarus lh. J Med Chem. 2002 Dec 5;45(25):5506-13. doi: 10.1021/jm020330p. J Med Chem. 2002. PMID: 12459018

4

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Jinsmaa Y, Bryant SD, Lazarus LH. Balboni G, et al. Among authors: lazarus lh. J Med Chem. 2002 Dec 5;45(25):5556-63. doi: 10.1021/jm020336e. J Med Chem. 2002. PMID: 12459023

5

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.

Okada Y, Tsuda Y, Fujita Y, Yokoi T, Sasaki Y, Ambo A, Konishi R, Nagata M, Salvadori S, Jinsmaa Y, Bryant SD, Lazarus LH. Okada Y, et al. Among authors: lazarus lh. J Med Chem. 2003 Jul 17;46(15):3201-9. doi: 10.1021/jm020459z. J Med Chem. 2003. PMID: 12852751

6

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: lazarus lh. Bioorg Med Chem. 2003 Dec 1;11(24):5435-41. doi: 10.1016/j.bmc.2003.09.039. Bioorg Med Chem. 2003. PMID: 14642588

7

Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.

Jinsmaa Y, Miyazaki A, Fujita Y, Li T, Fujisawa Y, Shiotani K, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y. Jinsmaa Y, et al. Among authors: lazarus lh. J Med Chem. 2004 May 6;47(10):2599-610. doi: 10.1021/jm0304616. J Med Chem. 2004. PMID: 15115401

8

Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.

Fujita Y, Tsuda Y, Li T, Motoyama T, Takahashi M, Shimizu Y, Yokoi T, Sasaki Y, Ambo A, Kita A, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Fujita Y, et al. Among authors: lazarus lh. J Med Chem. 2004 Jul 1;47(14):3591-9. doi: 10.1021/jm030649p. J Med Chem. 2004. PMID: 15214786

9

Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.

Balboni G, Salvadori S, Dal Piaz A, Bortolotti F, Argazzi R, Negri L, Lattanzi R, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: lazarus lh. J Med Chem. 2004 Dec 16;47(26):6541-6. doi: 10.1021/jm040128h. J Med Chem. 2004. PMID: 15588089

10

Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.

Li T, Fujita Y, Tsuda Y, Miyazaki A, Ambo A, Sasaki Y, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Li T, et al. Among authors: lazarus lh. J Med Chem. 2005 Jan 27;48(2):586-92. doi: 10.1021/jm049384k. J Med Chem. 2005. PMID: 15658871

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