Teesdale-Spittle P - Search Results

1

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.

Gaitanos TN, Buey RM, Díaz JF, Northcote PT, Teesdale-Spittle P, Andreu JM, Miller JH. Gaitanos TN, et al. Cancer Res. 2004 Aug 1;64(15):5063-7. doi: 10.1158/0008-5472.CAN-04-0771. Cancer Res. 2004. PMID: 15289305

2

βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.

Kanakkanthara A, Rowe MR, Field JJ, Northcote PT, Teesdale-Spittle PH, Miller JH. Kanakkanthara A, et al. Cancer Lett. 2015 Sep 1;365(2):251-60. doi: 10.1016/j.canlet.2015.06.001. Epub 2015 Jun 4. Cancer Lett. 2015. PMID: 26052091

3

Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.

Hanna R, Maass DR, Atkinson PH, Northcote PT, Teesdale-Spittle PH, Bellows DS, Miller JH. Hanna R, et al. Mol Biosyst. 2014 Jan;10(1):110-6. doi: 10.1039/c3mb70380k. Mol Biosyst. 2014. PMID: 24161989

4

Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics.

Kanakkanthara A, Teesdale-Spittle PH, Miller JH. Kanakkanthara A, et al. Anticancer Agents Med Chem. 2013 Jan;13(1):147-58. Anticancer Agents Med Chem. 2013. PMID: 22583426 Review.

5

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues.

Singh AJ, Razzak M, Teesdale-Spittle P, Gaitanos TN, Wilmes A, Paterson I, Goodman JM, Miller JH, Northcote PT. Singh AJ, et al. Org Biomol Chem. 2011 Jun 21;9(12):4456-66. doi: 10.1039/c0ob01127d. Epub 2011 Apr 21. Org Biomol Chem. 2011. PMID: 21512693

6

The cellular target specificity of pateamine A.

Matthews JH, Maass DR, Northcote PT, Atkinson PH, Teesdale-Spittle PH. Matthews JH, et al. Z Naturforsch C J Biosci. 2013 Sep-Oct;68(9-10):406-15. doi: 10.1515/znc-2013-9-1008. Z Naturforsch C J Biosci. 2013. PMID: 24459774 Free article.

7

The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network.

Venturi V, Davies C, Singh AJ, Matthews JH, Bellows DS, Northcote PT, Keyzers RA, Teesdale-Spittle PH. Venturi V, et al. J Biochem Mol Toxicol. 2012 Mar;26(3):94-100. doi: 10.1002/jbt.20414. Epub 2011 Dec 8. J Biochem Mol Toxicol. 2012. PMID: 22162108

8

Heptanosides from galactose-derived oxepenes via stereoselective addition reactions.

Batchelor R, Harvey JE, Northcote PT, Teesdale-Spittle P, Hoberg JO. Batchelor R, et al. J Org Chem. 2009 Oct 16;74(20):7627-32. doi: 10.1021/jo901706e. J Org Chem. 2009. PMID: 19754106

9

Synthesis of a simplified triazole analogue of pateamine A.

Hemi Cumming A, Brown SL, Tao X, Cuyamendous C, Field JJ, Miller JH, Harvey JE, Teesdale-Spittle PH. Hemi Cumming A, et al. Org Biomol Chem. 2016 Jun 14;14(22):5117-27. doi: 10.1039/c6ob00086j. Epub 2016 May 16. Org Biomol Chem. 2016. PMID: 27180995 Free PMC article.

10

Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.

Naineni SK, Liang J, Hull K, Cencic R, Zhu M, Northcote P, Teesdale-Spittle P, Romo D, Nagar B, Pelletier J. Naineni SK, et al. Among authors: teesdale spittle p. Cell Chem Biol. 2021 Jun 17;28(6):825-834.e6. doi: 10.1016/j.chembiol.2020.12.006. Epub 2021 Jan 6. Cell Chem Biol. 2021. PMID: 33412110 Free PMC article.

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