Takimoto A - Search Results

1

Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.

Yang Z, Sun X, Li S, Tan Y, Wang X, Zhang N, Yagi S, Takakura T, Kobayashi Y, Takimoto A, Yoshioka T, Suginaka A, Frenkel EP, Hoffman RM. Yang Z, et al. Among authors: takimoto a. Cancer Res. 2004 Aug 15;64(16):5775-8. doi: 10.1158/0008-5472.CAN-04-1406. Cancer Res. 2004. PMID: 15313919

2

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.

Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, Takimoto A, Yoshioka T, Lian C, Chen C, Zhang D, Zhang Y, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM. Yang Z, et al. Among authors: takimoto a. Cancer Res. 2004 Sep 15;64(18):6673-8. doi: 10.1158/0008-5472.CAN-04-1822. Cancer Res. 2004. PMID: 15374983

3

Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent.

Takakura T, Takimoto A, Notsu Y, Yoshida H, Ito T, Nagatome H, Ohno M, Kobayashi Y, Yoshioka T, Inagaki K, Yagi S, Hoffman RM, Esaki N. Takakura T, et al. Among authors: takimoto a. Cancer Res. 2006 Mar 1;66(5):2807-14. doi: 10.1158/0008-5472.CAN-05-3910. Cancer Res. 2006. PMID: 16510603

4

Development of Recombinant Methioninase for Cancer Treatment.

Hoffman RM, Tan Y, Li S, Han Q, Yagi S, Takakura T, Takimoto A, Inagaki K, Kudou D. Hoffman RM, et al. Among authors: takimoto a. Methods Mol Biol. 2019;1866:107-131. doi: 10.1007/978-1-4939-8796-2_10. Methods Mol Biol. 2019. PMID: 30725412

5

In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

Sun X, Yang Z, Li S, Tan Y, Zhang N, Wang X, Yagi S, Yoshioka T, Takimoto A, Mitsushima K, Suginaka A, Frenkel EP, Hoffman RM. Sun X, et al. Among authors: takimoto a. Cancer Res. 2003 Dec 1;63(23):8377-83. Cancer Res. 2003. PMID: 14678999

6

High-level expression and bulk crystallization of recombinant L-methionine gamma-lyase, an anticancer agent.

Takakura T, Ito T, Yagi S, Notsu Y, Itakura T, Nakamura T, Inagaki K, Esaki N, Hoffman RM, Takimoto A. Takakura T, et al. Among authors: takimoto a. Appl Microbiol Biotechnol. 2006 Mar;70(2):183-92. doi: 10.1007/s00253-005-0038-2. Epub 2005 Jul 13. Appl Microbiol Biotechnol. 2006. PMID: 16012835

7

Assay method for antitumor L-methionine gamma-lyase: comprehensive kinetic analysis of the complex reaction with L-methionine.

Takakura T, Mitsushima K, Yagi S, Inagaki K, Tanaka H, Esaki N, Soda K, Takimoto A. Takakura T, et al. Among authors: takimoto a. Anal Biochem. 2004 Apr 15;327(2):233-40. doi: 10.1016/j.ab.2004.01.024. Anal Biochem. 2004. PMID: 15051540

8

Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution.

Kudou D, Misaki S, Yamashita M, Tamura T, Takakura T, Yoshioka T, Yagi S, Hoffman RM, Takimoto A, Esaki N, Inagaki K. Kudou D, et al. Among authors: takimoto a. J Biochem. 2007 Apr;141(4):535-44. doi: 10.1093/jb/mvm055. Epub 2007 Feb 8. J Biochem. 2007. PMID: 17289792

9

Batch production of deacetyl 7-aminocephalosporanic acid by immobilized cephalosporin-C deacetylase.

Takimoto A, Takakura T, Tani H, Yagi S, Mitsushima K. Takimoto A, et al. Appl Microbiol Biotechnol. 2004 Aug;65(3):263-7. doi: 10.1007/s00253-004-1595-5. Epub 2004 Apr 7. Appl Microbiol Biotechnol. 2004. PMID: 15069587

10

High-level expression, purification, and some properties of a recombinant cephalosporin-C deacetylase.

Takimoto A, Yagi S, Mitsushima K. Takimoto A, et al. J Biosci Bioeng. 1999;87(4):456-62. doi: 10.1016/s1389-1723(99)80094-2. J Biosci Bioeng. 1999. PMID: 16232499

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