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Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate.
Rocha Lima CM, Green MR, Rotche R, Miller WH Jr, Jeffrey GM, Cisar LA, Morganti A, Orlando N, Gruia G, Miller LL. Rocha Lima CM, et al. Among authors: rotche r. J Clin Oncol. 2004 Sep 15;22(18):3776-83. doi: 10.1200/JCO.2004.12.082. J Clin Oncol. 2004. PMID: 15365074 Clinical Trial.