Lerner RA - Search Results

1

The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.

Zhu X, Tanaka F, Hu Y, Heine A, Fuller R, Zhong G, Olson AJ, Lerner RA, Barbas CF 3rd, Wilson IA. Zhu X, et al. Among authors: lerner ra. J Mol Biol. 2004 Nov 5;343(5):1269-80. doi: 10.1016/j.jmb.2004.08.102. J Mol Biol. 2004. PMID: 15491612

2

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.

Rader C, Turner JM, Heine A, Shabat D, Sinha SC, Wilson IA, Lerner RA, Barbas CF. Rader C, et al. Among authors: lerner ra. J Mol Biol. 2003 Sep 26;332(4):889-99. doi: 10.1016/s0022-2836(03)00992-6. J Mol Biol. 2003. PMID: 12972259

3

Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection.

Tanaka F, Fuller R, Shim H, Lerner RA, Barbas CF 3rd. Tanaka F, et al. Among authors: lerner ra. J Mol Biol. 2004 Jan 23;335(4):1007-18. doi: 10.1016/j.jmb.2003.11.014. J Mol Biol. 2004. PMID: 14698295

4

Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.

Zhu X, Wentworth P Jr, Wentworth AD, Eschenmoser A, Lerner RA, Wilson IA. Zhu X, et al. Among authors: lerner ra. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2247-52. doi: 10.1073/pnas.0307311101. Proc Natl Acad Sci U S A. 2004. PMID: 14982995 Free PMC article.

5

Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.

Sinha SC, Li LS, Watanabe S, Kaltgrad E, Tanaka F, Rader C, Lerner RA, Barbas CF 3rd. Sinha SC, et al. Among authors: lerner ra. Chemistry. 2004 Oct 25;10(21):5467-72. doi: 10.1002/chem.200400419. Chemistry. 2004. PMID: 15378729

6

Cofactor-containing antibodies: crystal structure of the original yellow antibody.

Zhu X, Wentworth P Jr, Kyle RA, Lerner RA, Wilson IA. Zhu X, et al. Among authors: lerner ra. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3581-5. doi: 10.1073/pnas.0600251103. Epub 2006 Feb 28. Proc Natl Acad Sci U S A. 2006. PMID: 16537445 Free PMC article.

7

Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes.

Wagner J, Lerner RA, Barbas CF 3rd. Wagner J, et al. Among authors: lerner ra. Science. 1995 Dec 15;270(5243):1797-800. doi: 10.1126/science.270.5243.1797. Science. 1995. PMID: 8525368

8

Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: aldolases.

Lerner RA, Barbas CF 3rd. Lerner RA, et al. Acta Chem Scand (Cph). 1996 Aug;50(8):672-8. doi: 10.3891/acta.chem.scand.50-0672. Acta Chem Scand (Cph). 1996. PMID: 8756355

9

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.

Barbas CF 3rd, Heine A, Zhong G, Hoffmann T, Gramatikova S, Björnestedt R, List B, Anderson J, Stura EA, Wilson IA, Lerner RA. Barbas CF 3rd, et al. Among authors: lerner ra. Science. 1997 Dec 19;278(5346):2085-92. doi: 10.1126/science.278.5346.2085. Science. 1997. PMID: 9405338

10

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.

Karlstrom A, Zhong G, Rader C, Larsen NA, Heine A, Fuller R, List B, Tanaka F, Wilson IA, Barbas CF 3rd, Lerner RA. Karlstrom A, et al. Among authors: lerner ra. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3878-83. doi: 10.1073/pnas.97.8.3878. Proc Natl Acad Sci U S A. 2000. PMID: 10760259 Free PMC article.

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