O'brien JA - Search Results

1

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL Jr, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR. Lindsley CW, et al. J Med Chem. 2004 Nov 18;47(24):5825-8. doi: 10.1021/jm049400d. J Med Chem. 2004. PMID: 15537338

2

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.

Hoffman JM, Wai JS, Thomas CM, Levin RB, O'Brien JA, Goldman ME. Hoffman JM, et al. J Med Chem. 1992 Oct 16;35(21):3784-91. doi: 10.1021/jm00099a006. J Med Chem. 1992. PMID: 1279172

3

Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.

Jasper JR, Harrell CM, O'Brien JA, Pettibone DJ. Jasper JR, et al. Life Sci. 1995;57(24):2253-61. doi: 10.1016/0024-3205(95)02218-8. Life Sci. 1995. PMID: 7475979

4

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Tucker TJ, Lyle TA, Wiscount CM, Britcher SF, Young SD, Sanders WM, Lumma WC, Goldman ME, O'Brien JA, Ball RG, et al. Tucker TJ, et al. J Med Chem. 1994 Jul 22;37(15):2437-44. doi: 10.1021/jm00041a023. J Med Chem. 1994. PMID: 7520079

5

Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.

Williams DL Jr, Murphy KL, Nolan NA, O'Brien JA, Pettibone DJ, Kivlighn SD, Krause SM, Lis EV Jr, Zingaro GJ, Gabel RA, et al. Williams DL Jr, et al. J Pharmacol Exp Ther. 1995 Dec;275(3):1518-26. J Pharmacol Exp Ther. 1995. PMID: 8531124

6

Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist.

Williams DL Jr, Murphy KL, Nolan NA, O'Brien JA, Lis EV Jr, Pettibone DJ, Clineschmidt BV, Krause SM, Veber DF, Naylor EM, Chakravarty PK, Walsh TF, Dhanoa DM, Chen A, Bagley SW, Fitch KJ, Greenlee WJ. Williams DL Jr, et al. Life Sci. 1996;58(14):1149-57. doi: 10.1016/0024-3205(96)00073-2. Life Sci. 1996. PMID: 8614266

7

Progress in the development of oxytocin antagonists for use in preterm labor.

Pettibone DJ, Guidotti M, Harrell CM, Jasper JR, Lis EV, O'Brien JA, Reiss DR, Woyden CJ, Bock MG, Evans BE, et al. Pettibone DJ, et al. Adv Exp Med Biol. 1995;395:601-12. Adv Exp Med Biol. 1995. PMID: 8714024 Review.

8

Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors.

Hess JF, Hey PJ, Chen TB, O'Brien J, Omalley SS, Pettibone DJ, Chang RS. Hess JF, et al. Biol Chem. 2001 Jan;382(1):123-9. doi: 10.1515/BC.2001.018. Biol Chem. 2001. PMID: 11258662

9

A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors.

Lemaire W, O'Brien JA, Burno M, Chaudhary AG, Dean DC, Williams PD, Freidinger RM, Pettibone DJ, Williams DL Jr. Lemaire W, et al. Eur J Pharmacol. 2002 Aug 16;450(1):19-28. doi: 10.1016/s0014-2999(02)02048-4. Eur J Pharmacol. 2002. PMID: 12176104

10

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL Jr. O'Brien JA, et al. Mol Pharmacol. 2003 Sep;64(3):731-40. doi: 10.1124/mol.64.3.731. Mol Pharmacol. 2003. PMID: 12920211

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