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RAS is regulated by the let-7 microRNA family.
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. Johnson SM, et al. Among authors: brown d. Cell. 2005 Mar 11;120(5):635-47. doi: 10.1016/j.cell.2005.01.014. Cell. 2005. PMID: 15766527 Free article.
The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, Weidhaas JB, Brown D, Bader AG, Slack FJ. Esquela-Kerscher A, et al. Among authors: brown d. Cell Cycle. 2008 Mar 15;7(6):759-64. doi: 10.4161/cc.7.6.5834. Epub 2008 Mar 3. Cell Cycle. 2008. PMID: 18344688
Regression of murine lung tumors by the let-7 microRNA.
Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ. Trang P, et al. Among authors: brown d. Oncogene. 2010 Mar 18;29(11):1580-7. doi: 10.1038/onc.2009.445. Epub 2009 Dec 7. Oncogene. 2010. PMID: 19966857 Free PMC article.
The let-7 microRNA represses cell proliferation pathways in human cells.
Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ. Johnson CD, et al. Among authors: brown d. Cancer Res. 2007 Aug 15;67(16):7713-22. doi: 10.1158/0008-5472.CAN-07-1083. Cancer Res. 2007. PMID: 17699775
The promise of microRNA replacement therapy.
Bader AG, Brown D, Winkler M. Bader AG, et al. Among authors: brown d. Cancer Res. 2010 Sep 15;70(18):7027-30. doi: 10.1158/0008-5472.CAN-10-2010. Epub 2010 Aug 31. Cancer Res. 2010. PMID: 20807816 Free PMC article. Review.
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