Springer BA - Search Results

1

2-Hydroxy-4,6-diamino-[1,3,5]triazines: a novel class of VEGF-R2 (KDR) tyrosine kinase inhibitors.

Baindur N, Chadha N, Brandt BM, Asgari D, Patch RJ, Schalk-Hihi C, Carver TE, Petrounia IP, Baumann CA, Ott H, Manthey C, Springer BA, Player MR. Baindur N, et al. Among authors: springer ba. J Med Chem. 2005 Mar 24;48(6):1717-20. doi: 10.1021/jm049372z. J Med Chem. 2005. PMID: 15771417

2

Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.

Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA. Schubert C, et al. Among authors: springer ba. J Biol Chem. 2007 Feb 9;282(6):4094-101. doi: 10.1074/jbc.M608183200. Epub 2006 Nov 28. J Biol Chem. 2007. PMID: 17132624 Free article.

3

Protein engineering of the colony-stimulating factor-1 receptor kinase domain for structural studies.

Schalk-Hihi C, Ma HC, Struble GT, Bayoumy S, Williams R, Devine E, Petrounia IP, Mezzasalma T, Zeng L, Schubert C, Grasberger B, Springer BA, Deckman IC. Schalk-Hihi C, et al. Among authors: springer ba. J Biol Chem. 2007 Feb 9;282(6):4085-93. doi: 10.1074/jbc.M608182200. Epub 2006 Nov 28. J Biol Chem. 2007. PMID: 17132625 Free article.

4

Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.

Xu G, Searle LL, Hughes TV, Beck AK, Connolly PJ, Abad MC, Neeper MP, Struble GT, Springer BA, Emanuel SL, Gruninger RH, Pandey N, Adams M, Moreno-Mazza S, Fuentes-Pesquera AR, Middleton SA, Greenberger LM. Xu G, et al. Among authors: springer ba. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3495-9. doi: 10.1016/j.bmcl.2008.05.024. Epub 2008 May 10. Bioorg Med Chem Lett. 2008. PMID: 18508264

5

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.

Xu G, Abad MC, Connolly PJ, Neeper MP, Struble GT, Springer BA, Emanuel SL, Pandey N, Gruninger RH, Adams M, Moreno-Mazza S, Fuentes-Pesquera AR, Middleton SA. Xu G, et al. Among authors: springer ba. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4615-9. doi: 10.1016/j.bmcl.2008.07.020. Epub 2008 Jul 10. Bioorg Med Chem Lett. 2008. PMID: 18653333

6

Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

Carver TE, Bordeau B, Cummings MD, Petrella EC, Pucci MJ, Zawadzke LE, Dougherty BA, Tredup JA, Bryson JW, Yanchunas J Jr, Doyle ML, Witmer MR, Nelen MI, DesJarlais RL, Jaeger EP, Devine H, Asel ED, Springer BA, Bone R, Salemme FR, Todd MJ. Carver TE, et al. Among authors: springer ba. J Biol Chem. 2005 Mar 25;280(12):11704-12. doi: 10.1074/jbc.M413278200. Epub 2005 Jan 5. J Biol Chem. 2005. PMID: 15634672 Free article.

7

Enhancing recombinant protein quality and yield by protein stability profiling.

Mezzasalma TM, Kranz JK, Chan W, Struble GT, Schalk-Hihi C, Deckman IC, Springer BA, Todd MJ. Mezzasalma TM, et al. Among authors: springer ba. J Biomol Screen. 2007 Apr;12(3):418-28. doi: 10.1177/1087057106297984. J Biomol Screen. 2007. PMID: 17438070

8

The effects of amino acid substitution at position E7 (residue 64) on the kinetics of ligand binding to sperm whale myoglobin.

Rohlfs RJ, Mathews AJ, Carver TE, Olson JS, Springer BA, Egeberg KD, Sligar SG. Rohlfs RJ, et al. Among authors: springer ba. J Biol Chem. 1990 Feb 25;265(6):3168-76. J Biol Chem. 1990. PMID: 2303446 Free article.

9

Analysis of the kinetic barriers for ligand binding to sperm whale myoglobin using site-directed mutagenesis and laser photolysis techniques.

Carver TE, Rohlfs RJ, Olson JS, Gibson QH, Blackmore RS, Springer BA, Sligar SG. Carver TE, et al. Among authors: springer ba. J Biol Chem. 1990 Nov 15;265(32):20007-20. J Biol Chem. 1990. PMID: 2246277 Free article.

10

The role of Val68(E11) in ligand binding to sperm whale myoglobin. Site-directed mutagenesis of a synthetic gene.

Egeberg KD, Springer BA, Sligar SG, Carver TE, Rohlfs RJ, Olson JS. Egeberg KD, et al. Among authors: springer ba. J Biol Chem. 1990 Jul 15;265(20):11788-95. J Biol Chem. 1990. PMID: 2114403 Free article.

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