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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples.
Beattie KA, Verma M, Brennan RJ, Clausznitzer D, Damian V, Leishman D, Spilker ME, Boras B, Li Z, Oziolor E, Rieger TR, Sher A. Beattie KA, et al. Among authors: spilker me. CPT Pharmacometrics Syst Pharmacol. 2024 Oct 16. doi: 10.1002/psp4.13227. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39412216 Free article. Review.
Volumetric imaging of optically cleared and fluorescently labeled animal tissue (VIOLA) for quantifying the 3D biodistribution of nanoparticles at cellular resolution in tumor tissue.
Rakhilin N, Yang B, Spilker ME, Manzuk LK, Montgomery MK, Shin E, Prashad N, Hwang J, Song Y, Loganzo F, Giddabasappa A, Ram S. Rakhilin N, et al. Among authors: spilker me. J Control Release. 2023 Feb;354:244-259. doi: 10.1016/j.jconrel.2022.12.060. Epub 2023 Jan 12. J Control Release. 2023. PMID: 36596340
Roadmap on plasticity and epigenetics in cancer.
Foo J, Basanta D, Rockne RC, Strelez C, Shah C, Ghaffarian K, Mumenthaler SM, Mitchell K, Lathia JD, Frankhouser D, Branciamore S, Kuo YH, Marcucci G, Velde RV, Marusyk A, Huang S, Hari K, Jolly MK, Hatzikirou H, Poels KE, Spilker ME, Shtylla B, Robertson-Tessi M, Anderson ARA. Foo J, et al. Among authors: spilker me. Phys Biol. 2022 Apr 18;19(3):10.1088/1478-3975/ac4ee2. doi: 10.1088/1478-3975/ac4ee2. Phys Biol. 2022. PMID: 35078159 Free PMC article. Review.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Cheng H, Orr STM, Bailey S, Brooun A, Chen P, Deal JG, Deng YL, Edwards MP, Gallego GM, Grodsky N, Huang B, Jalaie M, Kaiser S, Kania RS, Kephart SE, Lafontaine J, Ornelas MA, Pairish M, Planken S, Shen H, Sutton S, Zehnder L, Almaden CD, Bagrodia S, Falk MD, Gukasyan HJ, Ho C, Kang X, Kosa RE, Liu L, Spilker ME, Timofeevski S, Visswanathan R, Wang Z, Meng F, Ren S, Shao L, Xu F, Kath JC. Cheng H, et al. Among authors: spilker me. J Med Chem. 2021 Jan 14;64(1):644-661. doi: 10.1021/acs.jmedchem.0c01652. Epub 2020 Dec 24. J Med Chem. 2021. PMID: 33356246
A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor.
Chen W, Boras B, Sung T, Yu Y, Zheng J, Wang D, Hu W, Spilker ME, D'Argenio DZ. Chen W, et al. Among authors: spilker me. J Pharmacokinet Pharmacodyn. 2020 Apr;47(2):163-182. doi: 10.1007/s10928-020-09680-6. Epub 2020 Mar 11. J Pharmacokinet Pharmacodyn. 2020. PMID: 32162138 Free PMC article.
44 results