Hamel E - Search Results

1

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.

Marcus AI, Zhou J, O'Brate A, Hamel E, Wong J, Nivens M, El-Naggar A, Yao TP, Khuri FR, Giannakakou P. Marcus AI, et al. Among authors: hamel e. Cancer Res. 2005 May 1;65(9):3883-93. doi: 10.1158/0008-5472.CAN-04-3757. Cancer Res. 2005. PMID: 15867388 Free PMC article.

2

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Edler MC, et al. Among authors: hamel e. Biochemistry. 2005 Aug 30;44(34):11525-38. doi: 10.1021/bi050660m. Biochemistry. 2005. PMID: 16114889

3

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

Thomas SL, Zhong D, Zhou W, Malik S, Liotta D, Snyder JP, Hamel E, Giannakakou P. Thomas SL, et al. Among authors: hamel e. Cell Cycle. 2008 Aug;7(15):2409-17. doi: 10.4161/cc.6410. Epub 2008 Jun 9. Cell Cycle. 2008. PMID: 18682687 Free PMC article.

4

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.

Kanakkanthara A, Wilmes A, O'Brate A, Escuin D, Chan A, Gjyrezi A, Crawford J, Rawson P, Kivell B, Northcote PT, Hamel E, Giannakakou P, Miller JH. Kanakkanthara A, et al. Among authors: hamel e. Mol Cancer Ther. 2011 Aug;10(8):1419-29. doi: 10.1158/1535-7163.MCT-10-1057. Epub 2011 Jun 8. Mol Cancer Ther. 2011. PMID: 21653684 Free PMC article.

5

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

Kowalski RJ, Giannakakou P, Hamel E. Kowalski RJ, et al. Among authors: hamel e. J Biol Chem. 1997 Jan 24;272(4):2534-41. doi: 10.1074/jbc.272.4.2534. J Biol Chem. 1997. PMID: 8999970 Free article.

6

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E. Kowalski RJ, et al. Among authors: hamel e. Mol Pharmacol. 1997 Oct;52(4):613-22. Mol Pharmacol. 1997. PMID: 9380024

7

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

Pryor DE, O'Brate A, Bilcer G, Díaz JF, Wang Y, Wang Y, Kabaki M, Jung MK, Andreu JM, Ghosh AK, Giannakakou P, Hamel E. Pryor DE, et al. Among authors: hamel e. Biochemistry. 2002 Jul 23;41(29):9109-15. doi: 10.1021/bi020211b. Biochemistry. 2002. PMID: 12119025

8

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

Kingston DG, Chaudhary AG, Chordia MD, Gharpure M, Gunatilaka AA, Higgs PI, Rimoldi JM, Samala L, Jagtap PG, Giannakakou P, Jiang YQ, Lin CM, Hamel E, Long BH, Fairchild CR, Johnston KA. Kingston DG, et al. Among authors: hamel e. J Med Chem. 1998 Sep 10;41(19):3715-26. doi: 10.1021/jm980229d. J Med Chem. 1998. PMID: 9733497

9

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

Paull KD, Lin CM, Malspeis L, Hamel E. Paull KD, et al. Among authors: hamel e. Cancer Res. 1992 Jul 15;52(14):3892-900. Cancer Res. 1992. PMID: 1617665

10

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

Bai R, Schwartz RE, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Cancer Res. 1996 Oct 1;56(19):4398-406. Cancer Res. 1996. PMID: 8813133

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