Marcus AI - Search Results

1

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.

Marcus AI, Zhou J, O'Brate A, Hamel E, Wong J, Nivens M, El-Naggar A, Yao TP, Khuri FR, Giannakakou P. Marcus AI, et al. Cancer Res. 2005 May 1;65(9):3883-93. doi: 10.1158/0008-5472.CAN-04-3757. Cancer Res. 2005. PMID: 15867388 Free PMC article.

2

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM, Giannakakou P. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77. doi: 10.1074/jbc.M413471200. Epub 2005 Jan 13. J Biol Chem. 2005. PMID: 15653676 Free PMC article.

3

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Edler MC, et al. Among authors: marcus ai. Biochemistry. 2005 Aug 30;44(34):11525-38. doi: 10.1021/bi050660m. Biochemistry. 2005. PMID: 16114889

4

Farnesyltransferase inhibitors reverse taxane resistance.

Marcus AI, O'Brate AM, Buey RM, Zhou J, Thomas S, Khuri FR, Andreu JM, Díaz F, Giannakakou P. Marcus AI, et al. Cancer Res. 2006 Sep 1;66(17):8838-46. doi: 10.1158/0008-5472.CAN-06-0699. Cancer Res. 2006. PMID: 16951201 Free PMC article.

5

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function.

Schafer-Hales K, Iaconelli J, Snyder JP, Prussia A, Nettles JH, El-Naggar A, Khuri FR, Giannakakou P, Marcus AI. Schafer-Hales K, et al. Among authors: marcus ai. Mol Cancer Ther. 2007 Apr;6(4):1317-28. doi: 10.1158/1535-7163.MCT-06-0703. Mol Cancer Ther. 2007. PMID: 17431110 Clinical Trial.

6

The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells.

Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. Sun SY, et al. Among authors: marcus ai. J Biol Chem. 2007 Jun 29;282(26):18800-9. doi: 10.1074/jbc.M611438200. Epub 2007 May 9. J Biol Chem. 2007. PMID: 17493934 Free article.

7

Automatic microtubule tracking for QD-based in vivo cell imaging and drug efficacy study.

Kong KY, Marcus AI, Hong JY, Giannakakou P, Wang MD. Kong KY, et al. Among authors: marcus ai. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:3321-4. doi: 10.1109/IEMBS.2006.259750. Conf Proc IEEE Eng Med Biol Soc. 2006. PMID: 17947021

8

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.

Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. Zhang S, et al. Among authors: marcus ai. Cancer Res. 2008 Feb 1;68(3):740-8. doi: 10.1158/0008-5472.CAN-07-2989. Cancer Res. 2008. PMID: 18245474 Free article.

9

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition.

Zhong D, Liu X, Schafer-Hales K, Marcus AI, Khuri FR, Sun SY, Zhou W. Zhong D, et al. Among authors: marcus ai. Mol Cancer Ther. 2008 Apr;7(4):809-17. doi: 10.1158/1535-7163.MCT-07-0559. Mol Cancer Ther. 2008. PMID: 18413794

10

p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J. Kang S, et al. Among authors: marcus ai. J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15. J Clin Invest. 2010. PMID: 20234090 Free PMC article.

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