Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
Zhou J, Gupta K, Yao J, Ye K, Panda D, Giannakakou P, Joshi HC.
Zhou J, et al.
J Biol Chem. 2002 Oct 18;277(42):39777-85. doi: 10.1074/jbc.M203927200. Epub 2002 Aug 14.
J Biol Chem. 2002.
PMID: 12183452
Free article.
We have previously discovered the opium alkaloid noscapine as a microtubule interacting agent that binds to tubulin, alters the dynamics of microtubule assembly, and arrests mammalian cells at mitosis (Ye, K., Ke, Y., Keshava, N., Shanks, J., Kapp, J. A., Tekmal, R. …
We have previously discovered the opium alkaloid noscapine as a microtubule interacting agent that binds to tubulin, alters the dynamics of …