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Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C. Themis M, et al. Among authors: coutelle c. Mol Ther. 2005 Oct;12(4):763-71. doi: 10.1016/j.ymthe.2005.07.358. Mol Ther. 2005. PMID: 16084128 Free article.
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Waddington SN, Nivsarkar MS, Mistry AR, Buckley SM, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EG, Themis M, Coutelle C. Waddington SN, et al. Among authors: coutelle c. Blood. 2004 Nov 1;104(9):2714-21. doi: 10.1182/blood-2004-02-0627. Epub 2004 Jul 1. Blood. 2004. PMID: 15231566 Free article.
In utero gene therapy: current challenges and perspectives.
Waddington SN, Kramer MG, Hernandez-Alcoceba R, Buckley SM, Themis M, Coutelle C, Prieto J. Waddington SN, et al. Among authors: coutelle c. Mol Ther. 2005 May;11(5):661-76. doi: 10.1016/j.ymthe.2005.01.015. Mol Ther. 2005. PMID: 15851005 Free article. Review.
The concept of prenatal gene therapy.
Coutelle C, Waddington SN. Coutelle C, et al. Methods Mol Biol. 2012;891:1-7. doi: 10.1007/978-1-61779-873-3_1. Methods Mol Biol. 2012. PMID: 22648765
The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.
Nowrouzi A, Cheung WT, Li T, Zhang X, Arens A, Paruzynski A, Waddington SN, Osejindu E, Reja S, von Kalle C, Wang Y, Al-Allaf F, Gregory L, Themis M, Holder M, Dighe N, Ruthe A, Buckley SM, Bigger B, Montini E, Thrasher AJ, Andrews R, Roberts TP, Newbold RF, Coutelle C, Schmidt M, Themis M. Nowrouzi A, et al. Among authors: coutelle c. Mol Ther. 2013 Feb;21(2):324-37. doi: 10.1038/mt.2012.224. Epub 2012 Nov 13. Mol Ther. 2013. PMID: 23299800 Free PMC article.
Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature.
Condiotti R, Goldenberg D, Giladi H, Schnitzer-Perlman T, Waddington SN, Buckley SM, Heim D, Cheung W, Themis M, Coutelle C, Simerzin A, Osejindu E, Wege H, Themis M, Galun E. Condiotti R, et al. Among authors: coutelle c. Mol Ther. 2014 Jan;22(1):59-68. doi: 10.1038/mt.2013.193. Epub 2013 Aug 28. Mol Ther. 2014. PMID: 23982166 Free PMC article.
Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C. Themis M, et al. Among authors: coutelle c. Mol Ther. 2006 Apr;13(4):830. doi: 10.1016/j.ymthe.2005.10.003. Epub 2005 Nov 3. Mol Ther. 2006. PMID: 28189020 Free article. No abstract available.
241 results