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Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Hammerland LG, Johansson M, Malmström J, Mattsson JP, Minidis AB, Nilsson K, Peterson A, Wensbo D, Wållberg A, Osterlund K. Hammerland LG, et al. Among authors: osterlund k. Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. doi: 10.1016/j.bmcl.2006.01.100. Epub 2006 Feb 14. Bioorg Med Chem Lett. 2006. PMID: 16481165
Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Bach P, Nilsson K, Svensson T, Bauer U, Hammerland LG, Peterson A, Wållberg A, Osterlund K, Karis D, Boije M, Wensbo D. Bach P, et al. Among authors: osterlund k. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. doi: 10.1016/j.bmcl.2006.06.078. Epub 2006 Jul 11. Bioorg Med Chem Lett. 2006. PMID: 16837196
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Bach P, Antonsson T, Bylund R, Björkman JA, Österlund K, Giordanetto F, van Giezen JJ, Andersen SM, Zachrisson H, Zetterberg F. Bach P, et al. Among authors: osterlund k. J Med Chem. 2013 Sep 12;56(17):7015-24. doi: 10.1021/jm400820m. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23899349
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
Bäckbro K, Löwgren S, Osterlund K, Atepo J, Unge T, Hultén J, Bonham NM, Schaal W, Karlén A, Hallberg A. Bäckbro K, et al. Among authors: osterlund k. J Med Chem. 1997 Mar 14;40(6):898-902. doi: 10.1021/jm960588d. J Med Chem. 1997. PMID: 9083478
84 results