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An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells.
Kyriazi D, Voth L, Bader A, Ewert W, Gerlach J, Elfrink K, Franz P, Tsap MI, Schirmer B, Damiano-Guercio J, Hartmann FK, Plenge M, Salari A, Schöttelndreier D, Strienke K, Bresch N, Salinas C, Gutzeit HO, Schaumann N, Hussein K, Bähre H, Brüsch I, Claus P, Neumann D, Taft MH, Shcherbata HR, Ngezahayo A, Bähler M, Amiri M, Knölker HJ, Preller M, Tsiavaliaris G. Kyriazi D, et al. Among authors: gutzeit ho. Nat Commun. 2024 Nov 16;15(1):9947. doi: 10.1038/s41467-024-54181-6. Nat Commun. 2024. PMID: 39550360 Free PMC article.
In vitro and in vivo effects of inhibitors on actin and myosin.
Richter S, Martin R, Gutzeit HO, Knölker HJ. Richter S, et al. Among authors: gutzeit ho. Bioorg Med Chem. 2021 Jan 15;30:115928. doi: 10.1016/j.bmc.2020.115928. Epub 2020 Dec 9. Bioorg Med Chem. 2021. PMID: 33341499
Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ. Chinthalapudi K, et al. Among authors: gutzeit ho. J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16. J Biol Chem. 2011. PMID: 21680745 Free PMC article.
61 results