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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang HS, Schultz Jel J, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG. Zhao W, et al. Among authors: wang hs. Circulation. 2006 Feb 21;113(7):995-1004. doi: 10.1161/CIRCULATIONAHA.105.583351. Epub 2006 Feb 13. Circulation. 2006. PMID: 16476846
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.
Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW 2nd, Wang HS, Valdivia HH, Chu G, Kranias EG. Yuan Q, et al. Among authors: wang hs. Circulation. 2007 Jan 23;115(3):300-9. doi: 10.1161/CIRCULATIONAHA.106.654699. Epub 2007 Jan 15. Circulation. 2007. PMID: 17224479
Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
Qian J, Vafiadaki E, Florea SM, Singh VP, Song W, Lam CK, Wang Y, Yuan Q, Pritchard TJ, Cai W, Haghighi K, Rodriguez P, Wang HS, Sanoudou D, Fan GC, Kranias EG. Qian J, et al. Among authors: wang hs, wang y. Circ Res. 2011 Jun 10;108(12):1429-38. doi: 10.1161/CIRCRESAHA.110.237644. Epub 2011 Apr 14. Circ Res. 2011. PMID: 21493896 Free PMC article.
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim DH. Park CS, et al. Among authors: wang hs. Basic Res Cardiol. 2013 May;108(3):344. doi: 10.1007/s00395-013-0344-2. Epub 2013 Apr 4. Basic Res Cardiol. 2013. PMID: 23553082 Free PMC article.
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.
Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG. Singh VP, et al. Among authors: wang hs. J Am Heart Assoc. 2013 Oct 14;2(5):e000460. doi: 10.1161/JAHA.113.000460. J Am Heart Assoc. 2013. PMID: 24125847 Free PMC article.
1,529 results