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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang HS, Schultz Jel J, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG. Zhao W, et al. Circulation. 2006 Feb 21;113(7):995-1004. doi: 10.1161/CIRCULATIONAHA.105.583351. Epub 2006 Feb 13. Circulation. 2006. PMID: 16476846
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.
Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Pathak A, et al. Among authors: zhao w. Circ Res. 2005 Apr 15;96(7):756-66. doi: 10.1161/01.RES.0000161256.85833.fa. Epub 2005 Mar 3. Circ Res. 2005. PMID: 15746443
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.
Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW 2nd, Wang HS, Valdivia HH, Chu G, Kranias EG. Yuan Q, et al. Among authors: zhao w. Circulation. 2007 Jan 23;115(3):300-9. doi: 10.1161/CIRCULATIONAHA.106.654699. Epub 2007 Jan 15. Circulation. 2007. PMID: 17224479
The anti-apoptotic protein HAX-1 is a regulator of cardiac function.
Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG. Zhao W, et al. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20776-81. doi: 10.1073/pnas.0906998106. Epub 2009 Nov 17. Proc Natl Acad Sci U S A. 2009. PMID: 19920172 Free PMC article.
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