Leatherbarrow RJ - Search Results

1

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major.

Panethymitaki C, Bowyer PW, Price HP, Leatherbarrow RJ, Brown KA, Smith DF. Panethymitaki C, et al. Among authors: leatherbarrow rj. Biochem J. 2006 Jun 1;396(2):277-85. doi: 10.1042/BJ20051886. Biochem J. 2006. PMID: 16480339 Free PMC article.

2

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. Bowyer PW, et al. Among authors: leatherbarrow rj. Biochem J. 2007 Dec 1;408(2):173-80. doi: 10.1042/BJ20070692. Biochem J. 2007. PMID: 17714074 Free PMC article.

3

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

Heal WP, Wickramasinghe SR, Bowyer PW, Holder AA, Smith DF, Leatherbarrow RJ, Tate EW. Heal WP, et al. Among authors: leatherbarrow rj. Chem Commun (Camb). 2008 Jan 28;(4):480-2. doi: 10.1039/b716115h. Epub 2007 Nov 13. Chem Commun (Camb). 2008. PMID: 18188474

4

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Hutton JA, et al. Among authors: leatherbarrow rj. J Med Chem. 2014 Oct 23;57(20):8664-70. doi: 10.1021/jm5011397. Epub 2014 Oct 1. J Med Chem. 2014. PMID: 25238611 Free PMC article.

5

N-myristoyltransferase: a prospective drug target for protozoan parasites.

Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. Bowyer PW, et al. Among authors: leatherbarrow rj. ChemMedChem. 2008 Mar;3(3):402-8. doi: 10.1002/cmdc.200700301. ChemMedChem. 2008. PMID: 18324715 Review. No abstract available.

6

N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.

Brannigan JA, Smith BA, Yu Z, Brzozowski AM, Hodgkinson MR, Maroof A, Price HP, Meier F, Leatherbarrow RJ, Tate EW, Smith DF, Wilkinson AJ. Brannigan JA, et al. Among authors: leatherbarrow rj. J Mol Biol. 2010 Mar 5;396(4):985-99. doi: 10.1016/j.jmb.2009.12.032. Epub 2009 Dec 28. J Mol Biol. 2010. PMID: 20036251 Free PMC article.

7

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.

Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ. Brannigan JA, et al. Among authors: leatherbarrow rj. IUCrJ. 2014 Jun 17;1(Pt 4):250-60. doi: 10.1107/S2052252514013001. eCollection 2014 Jul 1. IUCrJ. 2014. PMID: 25075346 Free PMC article.

8

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. Paape D, et al. Among authors: leatherbarrow rj. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3363. doi: 10.1371/journal.pntd.0003363. eCollection 2014 Dec. PLoS Negl Trop Dis. 2014. PMID: 25522361 Free PMC article.

9

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Bell AS, et al. Among authors: leatherbarrow rj. J Med Chem. 2020 Jul 23;63(14):7740-7765. doi: 10.1021/acs.jmedchem.0c00570. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32575985 Free PMC article.

10

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Bell AS, et al. Among authors: leatherbarrow rj. PLoS Negl Trop Dis. 2012;6(4):e1625. doi: 10.1371/journal.pntd.0001625. Epub 2012 Apr 24. PLoS Negl Trop Dis. 2012. PMID: 22545171 Free PMC article.

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