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Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study.
Basile AM, Pantoni L, Pracucci G, Asplund K, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D; LADIS Study Group. Basile AM, et al. Among authors: asplund k. Cerebrovasc Dis. 2006;21(5-6):315-22. doi: 10.1159/000091536. Epub 2006 Feb 14. Cerebrovasc Dis. 2006. PMID: 16490940
Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology.
Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, O'brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D. Pantoni L, et al. Among authors: asplund k. Neuroepidemiology. 2005;24(1-2):51-62. doi: 10.1159/000081050. Neuroepidemiology. 2005. PMID: 15459510
White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study.
Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund LO, Basile AM, Pantoni L, Inzitari D, Waldemar G; LADIS study group. Ryberg C, et al. AJNR Am J Neuroradiol. 2008 Sep;29(8):1498-504. doi: 10.3174/ajnr.A1169. Epub 2008 Jun 12. AJNR Am J Neuroradiol. 2008. PMID: 18556357 Free PMC article.
Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort.
Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L; LADIS Study Group. Inzitari D, et al. BMJ. 2009 Jul 6;339:b2477. doi: 10.1136/bmj.b2477. BMJ. 2009. PMID: 19581317 Free PMC article.
409 results