Ulens C - Search Results

1

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma TK. Ulens C, et al. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3615-20. doi: 10.1073/pnas.0507889103. Epub 2006 Feb 27. Proc Natl Acad Sci U S A. 2006. PMID: 16505382 Free PMC article.

2

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. Dutertre S, et al. Among authors: ulens c. EMBO J. 2007 Aug 22;26(16):3858-67. doi: 10.1038/sj.emboj.7601785. Epub 2007 Jul 26. EMBO J. 2007. PMID: 17660751 Free PMC article.

3

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Ulens C, et al. J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g. J Med Chem. 2009. PMID: 19331415

4

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.

Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C. Brams M, et al. Among authors: ulens c. J Biol Chem. 2011 Feb 11;286(6):4420-8. doi: 10.1074/jbc.M110.188730. Epub 2010 Nov 29. J Biol Chem. 2011. PMID: 21115477 Free PMC article.

5

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C. Brams M, et al. Among authors: ulens c. PLoS Biol. 2011 Mar;9(3):e1001034. doi: 10.1371/journal.pbio.1001034. Epub 2011 Mar 29. PLoS Biol. 2011. PMID: 21468359 Free PMC article.

6

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.

Billen B, Spurny R, Brams M, van Elk R, Valera-Kummer S, Yakel JL, Voets T, Bertrand D, Smit AB, Ulens C. Billen B, et al. Among authors: ulens c. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9173-8. doi: 10.1073/pnas.1116397109. Epub 2012 May 22. Proc Natl Acad Sci U S A. 2012. PMID: 22619328 Free PMC article.

7

Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.

Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, Kozikowski AP. Zhang HK, et al. Among authors: ulens c. J Med Chem. 2012 Sep 27;55(18):8028-37. doi: 10.1021/jm3008739. Epub 2012 Sep 7. J Med Chem. 2012. PMID: 22928944 Free PMC article.

8

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.

Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Spurny R, et al. Among authors: ulens c. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035248 Free PMC article.

9

Structural basis of ligand recognition in 5-HT3 receptors.

Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C. Kesters D, et al. Among authors: ulens c. EMBO Rep. 2013 Jan;14(1):49-56. doi: 10.1038/embor.2012.189. Epub 2012 Nov 30. EMBO Rep. 2013. PMID: 23196367 Free PMC article.

10

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SCR, Ulens C. Spurny R, et al. Among authors: ulens c. J Biol Chem. 2013 Mar 22;288(12):8355-8364. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30. J Biol Chem. 2013. PMID: 23364792 Free PMC article.

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