Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
Jaxel C, Capranico G, Kerrigan D, Kohn KW, Pommier Y.
Jaxel C, et al. Among authors: capranico g.
J Biol Chem. 1991 Oct 25;266(30):20418-23.
J Biol Chem. 1991.
PMID: 1657924
Free article.
Analysis of base preferences around topoisomerase I cleavage sites in SV40 DNA indicated that camptothecin stabilized topoisomerase I preferentially at sites having a G immediately 3' to the cleaved bond. Experiments with 30-bp oligonucleotides showed that camptothecin pro …
Analysis of base preferences around topoisomerase I cleavage sites in SV40 DNA indicated that camptothecin stabilized topoisomerase I prefer …