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Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.
Phillips DP, Gao W, Yang Y, Zhang G, Lerario IK, Lau TL, Jiang J, Wang X, Nguyen DG, Bhat BG, Trotter C, Sullivan H, Welzel G, Landry J, Chen Y, Joseph SB, Li C, Gordon WP, Richmond W, Johnson K, Bretz A, Bursulaya B, Pan S, McNamara P, Seidel HM. Phillips DP, et al. Among authors: nguyen dg. J Med Chem. 2014 Apr 24;57(8):3263-82. doi: 10.1021/jm401731q. Epub 2014 Apr 4. J Med Chem. 2014. PMID: 24666203
Real-World Impact of an In-House Dihydropyrimidine Dehydrogenase (DPYD) Genotype Test on Fluoropyrimidine Dosing, Toxicities, and Hospitalizations at a Multisite Cancer Center.
Nguyen DG, Morris SA, Hamilton A, Kwange SO, Steuerwald N, Symanowski J, Moore DC, Hanson S, Mroz K, Lopes KE, Larck C, Musselwhite L, Kadakia KC, Koya B, Chai S, Osei-Boateng K, Kalapurakal S, Swift K, Hwang J, Patel JN. Nguyen DG, et al. JCO Precis Oncol. 2024 Jun;8:e2300623. doi: 10.1200/PO.23.00623. JCO Precis Oncol. 2024. PMID: 38935897 Free PMC article.
38 results