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RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
Plaza Menacho I, Koster R, van der Sloot AM, Quax WJ, Osinga J, van der Sluis T, Hollema H, Burzynski GM, Gimm O, Buys CH, Eggen BJ, Hofstra RM. Plaza Menacho I, et al. Among authors: hofstra rm. Cancer Res. 2005 Mar 1;65(5):1729-37. doi: 10.1158/0008-5472.CAN-04-2363. Cancer Res. 2005. PMID: 15753368
Current concepts in RET-related genetics, signaling and therapeutics.
Plaza-Menacho I, Burzynski GM, de Groot JW, Eggen BJ, Hofstra RM. Plaza-Menacho I, et al. Among authors: hofstra rm. Trends Genet. 2006 Nov;22(11):627-36. doi: 10.1016/j.tig.2006.09.005. Epub 2006 Sep 18. Trends Genet. 2006. PMID: 16979782 Review.
Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ. Plaza-Menacho I, et al. Among authors: hofstra rm. J Biol Chem. 2007 Mar 2;282(9):6415-24. doi: 10.1074/jbc.M608952200. Epub 2007 Jan 5. J Biol Chem. 2007. PMID: 17209045 Free article.
Oncological implications of RET gene mutations in Hirschsprung's disease.
Sijmons RH, Hofstra RM, Wijburg FA, Links TP, Zwierstra RP, Vermey A, Aronson DC, Tan-Sindhunata G, Brouwers-Smalbraak GJ, Maas SM, Buys CH. Sijmons RH, et al. Among authors: hofstra rm. Gut. 1998 Oct;43(4):542-7. doi: 10.1136/gut.43.4.542. Gut. 1998. PMID: 9824583 Free PMC article.
294 results