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Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.
Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM. Francis LK, et al. Among authors: ehrlich la. Clin Cancer Res. 2006 Nov 15;12(22):6826-35. doi: 10.1158/1078-0432.CCR-06-1331. Clin Cancer Res. 2006. PMID: 17121904
Pathophysiology of multiple myeloma bone disease.
Lentzsch S, Ehrlich LA, Roodman GD. Lentzsch S, et al. Among authors: ehrlich la. Hematol Oncol Clin North Am. 2007 Dec;21(6):1035-49, viii. doi: 10.1016/j.hoc.2007.08.009. Hematol Oncol Clin North Am. 2007. PMID: 17996587 Review.
FDA Approval Summary: Decitabine and Cedazuridine Tablets for Myelodysplastic Syndromes.
Kim N, Norsworthy KJ, Subramaniam S, Chen H, Manning ML, Kitabi E, Earp J, Ehrlich LA, Okusanya OO, Vallejo J, Gehrke BJ, de Claro RA, Pazdur R. Kim N, et al. Among authors: ehrlich la. Clin Cancer Res. 2022 Aug 15;28(16):3411-3416. doi: 10.1158/1078-0432.CCR-21-4498. Clin Cancer Res. 2022. PMID: 35435961 Free PMC article. Clinical Trial.
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