Downey GP - Search Results

1

Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.

Wang Q, Herrera Abreu MT, Siminovitch K, Downey GP, McCulloch CA. Wang Q, et al. Among authors: downey gp. J Biol Chem. 2006 Oct 13;281(41):31093-105. doi: 10.1074/jbc.M606392200. Epub 2006 Aug 11. J Biol Chem. 2006. PMID: 16905534 Free article.

2

The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts.

MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. MacGillivray M, et al. Among authors: downey gp. J Biol Chem. 2003 Jul 18;278(29):27190-8. doi: 10.1074/jbc.M213083200. Epub 2003 Apr 29. J Biol Chem. 2003. PMID: 12721296 Free article.

3

IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation.

Wang Q, Downey GP, Choi C, Kapus A, McCulloch CA. Wang Q, et al. Among authors: downey gp. FASEB J. 2003 Oct;17(13):1898-900. doi: 10.1096/fj.03-0069fje. Epub 2003 Aug 1. FASEB J. 2003. PMID: 14519666

4

SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.

Wang Q, Downey GP, Herrera-Abreu MT, Kapus A, McCulloch CA. Wang Q, et al. Among authors: downey gp. J Biol Chem. 2005 Mar 4;280(9):8397-406. doi: 10.1074/jbc.M410462200. Epub 2004 Nov 24. J Biol Chem. 2005. PMID: 15563458 Free article.

5

Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions.

Herrera Abreu MT, Wang Q, Vachon E, Suzuki T, Chow CW, Wang Y, Hong O, Villar J, McCulloch CA, Downey GP. Herrera Abreu MT, et al. Among authors: downey gp. J Cell Physiol. 2006 Apr;207(1):132-43. doi: 10.1002/jcp.20544. J Cell Physiol. 2006. PMID: 16250012

6

Signalling platforms that modulate the inflammatory response: new targets for drug development.

McCulloch CA, Downey GP, El-Gabalawy H. McCulloch CA, et al. Among authors: downey gp. Nat Rev Drug Discov. 2006 Oct;5(10):864-76. doi: 10.1038/nrd2109. Nat Rev Drug Discov. 2006. PMID: 17016427 Review.

7

Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation.

Herrera Abreu MT, Penton PC, Kwok V, Vachon E, Shalloway D, Vidali L, Lee W, McCulloch CA, Downey GP. Herrera Abreu MT, et al. Among authors: downey gp. Am J Physiol Cell Physiol. 2008 Apr;294(4):C931-44. doi: 10.1152/ajpcell.00359.2007. Epub 2008 Jan 23. Am J Physiol Cell Physiol. 2008. PMID: 18216165 Free PMC article.

8

Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.

Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA. Wang Q, et al. Among authors: downey gp. J Biol Chem. 2009 Jul 31;284(31):20763-72. doi: 10.1074/jbc.M808828200. Epub 2009 Jun 3. J Biol Chem. 2009. PMID: 19497848 Free PMC article.

9

Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression.

Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey GP, McCulloch CA. Wang Q, et al. Among authors: downey gp. J Biol Chem. 2010 Jul 16;285(29):22308-17. doi: 10.1074/jbc.M110.102426. Epub 2010 May 14. J Biol Chem. 2010. PMID: 20472558 Free PMC article.

10

Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK.

Wang Q, Downey GP, McCulloch CA. Wang Q, et al. Among authors: downey gp. FASEB J. 2011 Oct;25(10):3448-64. doi: 10.1096/fj.11-183459. Epub 2011 Jun 30. FASEB J. 2011. PMID: 21719512 Free PMC article.

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