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CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.

Mirghani RA, Sayi J, Aklillu E, Allqvist A, Jande M, Wennerholm A, Eriksen J, Herben VM, Jones BC, Gustafsson LL, Bertilsson L. Mirghani RA, et al. Among authors: allqvist a. Pharmacogenet Genomics. 2006 Sep;16(9):637-45. doi: 10.1097/01.fpc.0000230411.89973.1b. Pharmacogenet Genomics. 2006. PMID: 16906018

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Diczfalusy U, Miura J, Roh HK, Mirghani RA, Sayi J, Larsson H, Bodin KG, Allqvist A, Jande M, Kim JW, Aklillu E, Gustafsson LL, Bertilsson L. Diczfalusy U, et al. Among authors: allqvist a. Pharmacogenet Genomics. 2008 Mar;18(3):201-8. doi: 10.1097/FPC.0b013e3282f50ee9. Pharmacogenet Genomics. 2008. PMID: 18300941

CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir.

Josephson F, Allqvist A, Janabi M, Sayi J, Aklillu E, Jande M, Mahindi M, Burhenne J, Bottiger Y, Gustafsson LL, Haefeli WE, Bertilsson L. Josephson F, et al. Among authors: allqvist a. Clin Pharmacol Ther. 2007 May;81(5):708-12. doi: 10.1038/sj.clpt.6100117. Epub 2007 Feb 28. Clin Pharmacol Ther. 2007. PMID: 17329995

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.

Wennerholm A, Allqvist A, Svensson JO, Gustafsson LL, Mirghani RA, Bertilsson L. Wennerholm A, et al. Among authors: allqvist a. Eur J Clin Pharmacol. 2005 Apr;61(2):113-8. doi: 10.1007/s00228-004-0861-x. Epub 2005 Apr 2. Eur J Clin Pharmacol. 2005. PMID: 15806426 Clinical Trial.

Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

Allqvist A, Miura J, Bertilsson L, Mirghani RA. Allqvist A, et al. Eur J Clin Pharmacol. 2007 Feb;63(2):173-9. doi: 10.1007/s00228-006-0230-z. Epub 2007 Jan 3. Eur J Clin Pharmacol. 2007. PMID: 17200836

Simultaneous quantification of alprazolam, 4- and alpha-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry.

Allqvist A, Wennerholm A, Svensson JO, Mirghani RA. Allqvist A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 5;814(1):127-31. doi: 10.1016/j.jchromb.2004.10.012. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15607716

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