Giannakakou P - Search Results

1

Farnesyltransferase inhibitors reverse taxane resistance.

Marcus AI, O'Brate AM, Buey RM, Zhou J, Thomas S, Khuri FR, Andreu JM, Díaz F, Giannakakou P. Marcus AI, et al. Among authors: giannakakou p. Cancer Res. 2006 Sep 1;66(17):8838-46. doi: 10.1158/0008-5472.CAN-06-0699. Cancer Res. 2006. PMID: 16951201 Free PMC article.

2

Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol.

Zhou J, O'brate A, Zelnak A, Giannakakou P. Zhou J, et al. Among authors: giannakakou p. Cancer Res. 2004 Dec 1;64(23):8708-14. doi: 10.1158/0008-5472.CAN-04-2538. Cancer Res. 2004. PMID: 15574781

3

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM, Giannakakou P. Marcus AI, et al. Among authors: giannakakou p. J Biol Chem. 2005 Mar 25;280(12):11569-77. doi: 10.1074/jbc.M413471200. Epub 2005 Jan 13. J Biol Chem. 2005. PMID: 15653676 Free PMC article.

4

Targeting microtubules for cancer chemotherapy.

Zhou J, Giannakakou P. Zhou J, et al. Among authors: giannakakou p. Curr Med Chem Anticancer Agents. 2005 Jan;5(1):65-71. doi: 10.2174/1568011053352569. Curr Med Chem Anticancer Agents. 2005. PMID: 15720262 Review.

5

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.

Marcus AI, Zhou J, O'Brate A, Hamel E, Wong J, Nivens M, El-Naggar A, Yao TP, Khuri FR, Giannakakou P. Marcus AI, et al. Among authors: giannakakou p. Cancer Res. 2005 May 1;65(9):3883-93. doi: 10.1158/0008-5472.CAN-04-3757. Cancer Res. 2005. PMID: 15867388 Free PMC article.

6

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function.

Schafer-Hales K, Iaconelli J, Snyder JP, Prussia A, Nettles JH, El-Naggar A, Khuri FR, Giannakakou P, Marcus AI. Schafer-Hales K, et al. Among authors: giannakakou p. Mol Cancer Ther. 2007 Apr;6(4):1317-28. doi: 10.1158/1535-7163.MCT-06-0703. Mol Cancer Ther. 2007. PMID: 17431110 Clinical Trial.

7

Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies.

Kauh J, Chanel-Vos C, Escuin D, Fanucchi MP, Harvey RD, Saba N, Shin DM, Gal A, Pan L, Kutner M, Ramalingam SS, Bender L, Marcus A, Giannakakou P, Khuri FR. Kauh J, et al. Among authors: giannakakou p. Cancer. 2011 Sep 1;117(17):4049-59. doi: 10.1002/cncr.26004. Epub 2011 Mar 1. Cancer. 2011. PMID: 21365629 Free PMC article. Clinical Trial.

8

The importance of p53 location: nuclear or cytoplasmic zip code?

O'Brate A, Giannakakou P. O'Brate A, et al. Among authors: giannakakou p. Drug Resist Updat. 2003 Dec;6(6):313-22. doi: 10.1016/j.drup.2003.10.004. Drug Resist Updat. 2003. PMID: 14744495 Review.

9

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Edler MC, et al. Among authors: giannakakou p. Biochemistry. 2005 Aug 30;44(34):11525-38. doi: 10.1021/bi050660m. Biochemistry. 2005. PMID: 16114889

10

Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele.

Wang Y, O'Brate A, Zhou W, Giannakakou P. Wang Y, et al. Among authors: giannakakou p. Cell Cycle. 2005 Dec;4(12):1847-53. doi: 10.4161/cc.4.12.2264. Epub 2005 Dec 18. Cell Cycle. 2005. PMID: 16294009 Free PMC article.

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