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Probing a protein-protein interaction by in vitro evolution.
Thom G, Cockroft AC, Buchanan AG, Candotti CJ, Cohen ES, Lowne D, Monk P, Shorrock-Hart CP, Jermutus L, Minter RR. Thom G, et al. Among authors: jermutus l. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7619-24. doi: 10.1073/pnas.0602341103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684878 Free PMC article.
Tailored amino acid diversity for the evolution of antibody affinity.
González-Muñoz A, Bokma E, O'Shea D, Minton K, Strain M, Vousden K, Rossant C, Jermutus L, Minter R. González-Muñoz A, et al. Among authors: jermutus l. MAbs. 2012 Nov-Dec;4(6):664-72. doi: 10.4161/mabs.21728. Epub 2012 Aug 27. MAbs. 2012. PMID: 22926024 Free PMC article.
Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis.
Minter RR, Cohen ES, Wang B, Liang M, Vainshtein I, Rees G, Eghobamien L, Harrison P, Sims DA, Matthews C, Wilkinson T, Monk P, Drinkwater C, Fabri L, Nash A, McCourt M, Jermutus L, Roskos L, Anderson IK, Sleeman MA. Minter RR, et al. Among authors: jermutus l. Br J Pharmacol. 2013 Jan;168(1):200-11. doi: 10.1111/j.1476-5381.2012.02173.x. Br J Pharmacol. 2013. PMID: 22913645 Free PMC article.
Improved drug-like properties of therapeutic proteins by directed evolution.
Buchanan A, Ferraro F, Rust S, Sridharan S, Franks R, Dean G, McCourt M, Jermutus L, Minter R. Buchanan A, et al. Among authors: jermutus l. Protein Eng Des Sel. 2012 Oct;25(10):631-8. doi: 10.1093/protein/gzs054. Epub 2012 Aug 31. Protein Eng Des Sel. 2012. PMID: 22942395 Free PMC article.
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Sandercock AM, Rust S, Guillard S, Sachsenmeier KF, Holoweckyj N, Hay C, Flynn M, Huang Q, Yan K, Herpers B, Price LS, Soden J, Freeth J, Jermutus L, Hollingsworth R, Minter R. Sandercock AM, et al. Among authors: jermutus l. Mol Cancer. 2015 Jul 31;14:147. doi: 10.1186/s12943-015-0415-0. Mol Cancer. 2015. PMID: 26227951 Free PMC article.
82 results