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Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ. Plaza-Menacho I, et al. Among authors: hollema h. J Biol Chem. 2007 Mar 2;282(9):6415-24. doi: 10.1074/jbc.M608952200. Epub 2007 Jan 5. J Biol Chem. 2007. PMID: 17209045 Free article.
RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
Plaza Menacho I, Koster R, van der Sloot AM, Quax WJ, Osinga J, van der Sluis T, Hollema H, Burzynski GM, Gimm O, Buys CH, Eggen BJ, Hofstra RM. Plaza Menacho I, et al. Among authors: hollema h. Cancer Res. 2005 Mar 1;65(5):1729-37. doi: 10.1158/0008-5472.CAN-04-2363. Cancer Res. 2005. PMID: 15753368
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients.
Westra JL, Schaapveld M, Hollema H, de Boer JP, Kraak MM, de Jong D, ter Elst A, Mulder NH, Buys CH, Hofstra RM, Plukker JT. Westra JL, et al. Among authors: hollema h. J Clin Oncol. 2005 Aug 20;23(24):5635-43. doi: 10.1200/JCO.2005.04.096. J Clin Oncol. 2005. PMID: 16110022 Clinical Trial.
No association between two MLH3 variants (S845G and P844L)and colorectal cancer risk.
de Jong MM, Hofstra RM, Kooi KA, Westra JL, Berends MJ, Wu Y, Hollema H, van der Sluis T, van der Graaf WT, de Vries EG, Schaapveld M, Sijmons RH, te Meerman GJ, Kleibeuker JH. de Jong MM, et al. Among authors: hollema h. Cancer Genet Cytogenet. 2004 Jul 1;152(1):70-1. doi: 10.1016/j.cancergencyto.2003.10.008. Cancer Genet Cytogenet. 2004. PMID: 15193445
277 results