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1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism.
Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA 4th, Hsieh JC, Slater SA, Hsieh G, Kaczmarska M, Jurutka PW, Kolek OI, Ghishan FK, Haussler MR. Barthel TK, et al. Among authors: kolek oi. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):381-8. doi: 10.1016/j.jsbmb.2006.12.054. Epub 2007 Feb 12. J Steroid Biochem Mol Biol. 2007. PMID: 17293108
1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter.
Hines ER, Kolek OI, Jones MD, Serey SH, Sirjani NB, Kiela PR, Jurutka PW, Haussler MR, Collins JF, Ghishan FK. Hines ER, et al. Among authors: kolek oi. J Biol Chem. 2004 Nov 5;279(45):46406-14. doi: 10.1074/jbc.M404278200. Epub 2004 Aug 25. J Biol Chem. 2004. PMID: 15337762 Free article.
1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport.
Kolek OI, Hines ER, Jones MD, LeSueur LK, Lipko MA, Kiela PR, Collins JF, Haussler MR, Ghishan FK. Kolek OI, et al. Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1036-42. doi: 10.1152/ajpgi.00243.2005. Epub 2005 Jul 14. Am J Physiol Gastrointest Liver Physiol. 2005. PMID: 16020653 Free article.