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The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Warner N, Locarnini S, Kuiper M, Bartholomeusz A, Ayres A, Yuen L, Shaw T. Warner N, et al. Among authors: bartholomeusz a. Antimicrob Agents Chemother. 2007 Jul;51(7):2285-92. doi: 10.1128/AAC.01499-06. Epub 2007 Apr 16. Antimicrob Agents Chemother. 2007. PMID: 17438047 Free PMC article.
The hepatitis B virus and common mutants.
Locarnini S, McMillan J, Bartholomeusz A. Locarnini S, et al. Among authors: bartholomeusz a. Semin Liver Dis. 2003 Feb;23(1):5-20. doi: 10.1055/s-2003-37587. Semin Liver Dis. 2003. PMID: 12616447 Review.
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Tenney DJ, Levine SM, Rose RE, Walsh AW, Weinheimer SP, Discotto L, Plym M, Pokornowski K, Yu CF, Angus P, Ayres A, Bartholomeusz A, Sievert W, Thompson G, Warner N, Locarnini S, Colonno RJ. Tenney DJ, et al. Among authors: bartholomeusz a. Antimicrob Agents Chemother. 2004 Sep;48(9):3498-507. doi: 10.1128/AAC.48.9.3498-3507.2004. Antimicrob Agents Chemother. 2004. PMID: 15328117 Free PMC article.
46 results