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The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Warner N, Locarnini S, Kuiper M, Bartholomeusz A, Ayres A, Yuen L, Shaw T. Warner N, et al. Among authors: locarnini s. Antimicrob Agents Chemother. 2007 Jul;51(7):2285-92. doi: 10.1128/AAC.01499-06. Epub 2007 Apr 16. Antimicrob Agents Chemother. 2007. PMID: 17438047 Free PMC article.
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Preiss S, Littlejohn M, Angus P, Thompson A, Desmond P, Lewin SR, Sasadeusz J, Matthews G, Dore GJ, Shaw T, Sozzi V, Yuen L, Lau G, Ayres A, Thio C, Avihingsanon A, Ruxrungtham K, Locarnini S, Revill PA. Preiss S, et al. Among authors: locarnini s. Hepatology. 2008 Sep;48(3):741-9. doi: 10.1002/hep.22386. Hepatology. 2008. PMID: 18571815 Free PMC article.
Mechanisms of hepatitis B virus resistance development.
Warner N, Locarnini S. Warner N, et al. Among authors: locarnini s. Intervirology. 2014;57(3-4):218-24. doi: 10.1159/000360940. Epub 2014 Jul 15. Intervirology. 2014. PMID: 25034491 Free article.
The hepatitis B virus and common mutants.
Locarnini S, McMillan J, Bartholomeusz A. Locarnini S, et al. Semin Liver Dis. 2003 Feb;23(1):5-20. doi: 10.1055/s-2003-37587. Semin Liver Dis. 2003. PMID: 12616447 Review.
390 results