Hoekstra WJ - Search Results

1

Co-crystal structure guided array synthesis of PPARgamma inverse agonists.

Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ. Trump RP, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. doi: 10.1016/j.bmcl.2007.04.111. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17533125

2

Design and synthesis of an array of selective androgen receptor modulators.

Trump RP, Blanc JB, Stewart EL, Brown PJ, Caivano M, Gray DW, Hoekstra WJ, Willson TM, Han B, Turnbull P. Trump RP, et al. Among authors: hoekstra wj. J Comb Chem. 2007 Jan-Feb;9(1):107-14. doi: 10.1021/cc060096e. J Comb Chem. 2007. PMID: 17206838

3

Recent advances in peroxisome proliferator-activated receptor science.

Shearer BG, Hoekstra WJ. Shearer BG, et al. Among authors: hoekstra wj. Curr Med Chem. 2003 Feb;10(4):267-80. doi: 10.2174/0929867033368295. Curr Med Chem. 2003. PMID: 12570700 Review.

4

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.

Hoekstra WJ, Patel HS, Liang X, Blanc JB, Heyer DO, Willson TM, Iannone MA, Kadwell SH, Miller LA, Pearce KH, Simmons CA, Shearin J. Hoekstra WJ, et al. J Med Chem. 2005 Mar 24;48(6):2243-7. doi: 10.1021/jm040154f. J Med Chem. 2005. PMID: 15771467

5

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

Wiethe RW, Stewart EL, Drewry DH, Gray DW, Mehbob A, Hoekstra WJ. Wiethe RW, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3777-9. doi: 10.1016/j.bmcl.2006.04.055. Epub 2006 May 5. Bioorg Med Chem Lett. 2006. PMID: 16678409

6

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists.

Jones DG, Liang X, Stewart EL, Noe RA, Kallander LS, Madauss KP, Williams SP, Thompson SK, Gray DW, Hoekstra WJ. Jones DG, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3203-6. doi: 10.1016/j.bmcl.2005.05.001. Bioorg Med Chem Lett. 2005. PMID: 15925510

7

Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.

Dyatkin AB, Hoekstra WJ, Hlasta DJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Gunnet JW, Hageman W, Look R, Maryanoff BE. Dyatkin AB, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3081-4. doi: 10.1016/s0960-894x(02)00649-2. Bioorg Med Chem Lett. 2002. PMID: 12372506

8

Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308.

Hoekstra WJ, Maryanoff BE, Damiano BP, Andrade-Gordon P, Cohen JH, Costanzo MJ, Haertlein BJ, Hecker LR, Hulshizer BL, Kauffman JA, Keane P, McComsey DF, Mitchell JA, Scott L, Shah RD, Yabut SC. Hoekstra WJ, et al. J Med Chem. 1999 Dec 16;42(25):5254-65. doi: 10.1021/jm990418b. J Med Chem. 1999. PMID: 10602710

9

Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.

Matthews JM, Greco MN, Hecker LR, Hoekstra WJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Maryanoff BE. Matthews JM, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2003 Feb 24;13(4):753-6. doi: 10.1016/s0960-894x(02)01059-4. Bioorg Med Chem Lett. 2003. PMID: 12639574

10

Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.

De Corte BL, Kinney WA, Liu L, Ghosh S, Brunner L, Hoekstra WJ, Santulli RJ, Tuman RW, Baker J, Burns C, Proost JC, Tounge BA, Damiano BP, Maryanoff BE, Johnson DL, Galemmo RA Jr. De Corte BL, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. doi: 10.1016/j.bmcl.2004.06.061. Bioorg Med Chem Lett. 2004. PMID: 15380233

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