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Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
Chamian F, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG, Lowes MA. Chamian F, et al. Among authors: lowes ma. J Transl Med. 2007 Jun 7;5:27. doi: 10.1186/1479-5876-5-27. J Transl Med. 2007. PMID: 17555598 Free PMC article. Clinical Trial.
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris.
Chamian F, Lowes MA, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG. Chamian F, et al. Among authors: lowes ma. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2075-80. doi: 10.1073/pnas.0409569102. Epub 2005 Jan 25. Proc Natl Acad Sci U S A. 2005. PMID: 15671179 Free PMC article. Clinical Trial.
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).
Lowes MA, Chamian F, Abello MV, Fuentes-Duculan J, Lin SL, Nussbaum R, Novitskaya I, Carbonaro H, Cardinale I, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Wittkowski KM, Papp K, Garovoy M, Dummer W, Steinman RM, Krueger JG. Lowes MA, et al. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19057-62. doi: 10.1073/pnas.0509736102. Proc Natl Acad Sci U S A. 2005. PMID: 16380428 Free PMC article.
Pathogenesis and therapy of psoriasis.
Lowes MA, Bowcock AM, Krueger JG. Lowes MA, et al. Nature. 2007 Feb 22;445(7130):866-73. doi: 10.1038/nature05663. Nature. 2007. PMID: 17314973 Review.
138 results