Lehman-McKeeman LD - Search Results

1

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD. Foster WR, et al. Toxicol Pathol. 2007 Aug;35(5):621-35. doi: 10.1080/01926230701419063. Toxicol Pathol. 2007. PMID: 17654404 Review.

2

p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.

Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD. Nelson DM, et al. Toxicol Sci. 2006 Dec;94(2):272-80. doi: 10.1093/toxsci/kfl115. Epub 2006 Sep 25. Toxicol Sci. 2006. PMID: 17000718

3

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B. Otieno MA, et al. Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216. Epub 2016 Oct 20. Toxicol Sci. 2017. PMID: 28025230

4

Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling.

Aranibar N, Bhaskaran V, Ott KH, Vassallo J, Nelson D, Lecureux L, Gong L, Stryker S, Lehman-McKeeman L. Aranibar N, et al. Magn Reson Chem. 2009 Dec;47 Suppl 1:S12-9. doi: 10.1002/mrc.2503. Magn Reson Chem. 2009. PMID: 19768707

5

Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats.

Wong H, Lehman-McKeeman LD, Grubb MF, Grossman SJ, Bhaskaran VM, Solon EG, Shen HS, Gerson RJ, Car BD, Zhao B, Gemzik B. Wong H, et al. Toxicol Sci. 2005 Apr;84(2):232-42. doi: 10.1093/toxsci/kfi094. Epub 2005 Jan 26. Toxicol Sci. 2005. PMID: 15673846

6

Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.

Ren H, Vallanat B, Nelson DM, Yeung LWY, Guruge KS, Lam PKS, Lehman-McKeeman LD, Corton JC. Ren H, et al. Reprod Toxicol. 2009 Jun;27(3-4):266-277. doi: 10.1016/j.reprotox.2008.12.011. Epub 2009 Jan 3. Reprod Toxicol. 2009. PMID: 19162173

7

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, Roth RA. Luyendyk JP, et al. Toxicol Sci. 2006 Apr;90(2):569-85. doi: 10.1093/toxsci/kfj103. Epub 2006 Jan 16. Toxicol Sci. 2006. PMID: 16415329

8

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.

Lecureux L, Dieter MZ, Nelson DM, Watson L, Wong H, Gemzik B, Klaassen CD, Lehman-McKeeman LD. Lecureux L, et al. Toxicol Sci. 2009 Apr;108(2):482-91. doi: 10.1093/toxsci/kfp026. Epub 2009 Feb 11. Toxicol Sci. 2009. PMID: 19211616

9

Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.

Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD. Gong L, et al. Toxicol Sci. 2011 Aug;122(2):587-97. doi: 10.1093/toxsci/kfr114. Epub 2011 May 10. Toxicol Sci. 2011. PMID: 21561886

10

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, Roth RA. Luyendyk JP, et al. J Pharmacol Exp Ther. 2006 May;317(2):635-43. doi: 10.1124/jpet.105.096305. Epub 2006 Jan 9. J Pharmacol Exp Ther. 2006. PMID: 16401727

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